摘要
目的观察他克莫司软膏治疗皮炎湿疹的疗效及对外周血Th1、Th2细胞因子水平的影响。方法选择2013年7月至2015年2月鞍山钢铁集团公司总医院收治的74例皮炎湿疹患者,依据随机数字表法分为观察组和对照组,各37例。对照组采用丁酸氢化可的松软膏,在每晚对患处进行清洁后,进行1次涂抹,疗程为1个月;观察组患者采取他克莫司软膏,每天晚上对患处进行清洁后,进行1次涂抹,疗程为1个月。观察两组患者治疗前后外周血Th1、Th2细胞因子水平及瘙痒程度评分。比较两组患者治疗后的临床疗效。结果治疗后,观察组患者的总有效率显著高于对照组[91.89%(34/37)比67.57%(25/37)],差异有统计学意义(P<0.05)。治疗后,观察组患者的白细胞介素2(IL-2)、肿瘤坏死因子α(TNF-α)、干扰素γ、IL-6均高于对照组[(45±10)ng/L比(35±6)ng/L、(53±10)ng/L比(45±9)ng/L、(48±10)ng/L比(42±8)ng/L、(58.32±10.53)ng/L比(47.15±9.21)ng/L](P<0.05),IL-4、IL-5均低于对照组[(32.98±8.07)ng/L比(37.02±9.02)ng/L、(52.34±8.54)ng/L比(58.02±9.21)ng/L](P<0.01)。治疗后1个月,观察组患者的视觉模拟评分显著低于对照组[(3.2±0.3)分比(4.1±0.8)分](P<0.05)。结论他克莫司软膏治疗皮炎湿疹,能明显改善患者的外周血Th1、Th2细胞因子水平,可缓解患者的瘙痒程度,临床疗效良好,安全性高。
Objective To study the therapeutic effect of tacrolimus ointment on dermatitis and eczema and the influence on peripheral blood Th1, Th2 level. Methods Total of 74 patients with dermatitis and eczema in General Hospital of Anshan Iron And Steel Group Corporation from Jul. 2013 to Feb. 2015 were included in the study. They were divided into observation group and control group according to random number table method. The observation group received tacrolimus ointment every night after cleaning the affected area ; the control group received hydrocortisone butyrate ointment after cleaning the affected area, once per day for a month. The peripheral blood Th1 ,Th2 cytokines and pruritus severity score of the two groups before and after treatment were compared. The clinical efficacy of the two groups after treatment was compared. Results After treatment, the total effect of observation groupwas higher than the control group [ 91.89% （ 34/37 ） vs 67.57 % （25/37） ], the difference was statistically significant （ P 〈 0.05 ）. After treatment, IL-2, TNF-α, interferon-γ ,IL-6 of the observation were higher than the control group [ （45 ± 10 ） ng/L vs （35 ± 6 ） rig/L, （53 ± 10） ng/L vs （45 ±9） ng/L, （48±10） ng/L vs （42 ± 8） ng/L, （58. 32 ± 10. 53） ng/L vs （47. 15 ±9. 21） ng/L] （P 〈0.05） ,IL-4 ,IL-5 were lower than the control group[ （32.98 ± 8.07） ng/L vs （37.02 ± 9. 02 ） rig/L, （52.34 ± 8.54） ng/L vs （58.02 ± 9.21 ） ng/L ] （ P 〈 0.01 ）. One month after treatment, VAS score of the observation group was significantly lower than the control group[ （ 3.21 ± 0.3 ） scores vs （4. 1 ± 0. 8） scores ] （P 〈 0. 05 ）. Conclusion Tacrolimus ointment can significantly improve the peripheral blood Thl ,Th2 cytokines in the treatment of dermatitis and eczema,and relieve itching,with good clinical efficacy and safety.
出处
《医学综述》
2016年第3期596-599,共4页
Medical Recapitulate
