摘要
目的:探讨卡巴拉汀持续及其联合体针、醒窍活血汤治疗老年痴呆的效果。方法:选取医院收治的老年痴呆患者82例作为研究对象,采用数字随机对照表将患者分为对照组和观察组,对照组予以卡巴拉汀持续治疗,观察组在对照组基础上辅以体针、醒窍活血汤治疗,行AD评估量表-认知分量表(ADAS-cog)、简易智能状态检查量表(MMSE)、日常生活能力评分量表(ADL)评分,观察两组治疗效果,分析两组不良用药反应。结果:观察组治疗有效率为85.37%显著高于对照组63.41%,差异具有统计学意义(P<0.05);观察组治疗后ADAS-cog评分为(43.65±4.26)分较对照组低,MMSE评分为(15.06±3.54)分较对照组高,差异具有统计学意义(P<0.05);观察组1年间ADAS-cog评分、MMSE评分稳定持续时间分别为(5.02±0.59)月、(5.87±0.66)月较对照组长,差异具有统计学意义(P<0.05)。结论:卡巴拉汀联合体针、醒窍活血汤治疗老年痴呆,能够延缓疾病衰退进程,效果显著。
Objective： To explore the effect of continuous rivastigmine combined with body acupuncture and Xingqiao Huoxue Decoction in the treatment of senile dementia. Methods： 82 cases of patients with senile dementia admitted into the hospital were selected as the research objects and were divided into the control group and the observation group by random number table. The control group was treated with continuous rivastigmine while the observation group with body acupuncture and Xingqiao Huoxue Decoction based on the treatment of the control group. With AD assessment scale-cognitive component scale（ ADAS COG）,mini mental state examination scale（ MMSE） and ability of daily life（ ADL） rating scale,the therapeutic effects of the two groups were observed and adverse drug reactions in the two groups were analyzed. Results： The effective rate in the observation group was 85.37% which was significantly higher than 63.41% of the control group and the difference was statistically significant（ P〈0.05）. ADAS cog score of the observation group after the treatment was（ 43.65±4.26） which was lower than that of the control group while MMSE score（ 15.06±3.54） was higher than that of the control group. The differences were statistically significant（ P〈0.05）. In a year,the stable duration ADAS-cog score and MMSE score in the observation group were respectively（ 5.02± 0.59） months and（ 5. 87 ± 0. 66） months which were longer than those in the control group and the difference was statistically significant（ P〈0. 05）. Conclusion：Rivastigmine combined with body acupuncture and Xingqiao Huoxue Decoction in the treatment of senile dementia can delay the decline process of the disease and the effect is significant.
出处
《中华中医药学刊》
CAS
北大核心
2016年第2期428-430,共3页
Chinese Archives of Traditional Chinese Medicine
基金
浙江省医药卫生科学研究基金项目(2012YB013)
关键词
老年痴呆
体针
醒窍活血汤
卡巴拉汀
认知功能
senile dementia
body acupuncture
Xingqiao Huoxue Decoction
rivastigmine
cognitive function
