摘要
瘢痕修复是心肌梗死后最常见的修复方式,心外膜来源细胞与骨髓来源细胞相互作用提供了瘢痕形成的细胞骨架,磷脂酶D1可抑制梗死后心室重塑,减少瘢痕形成,白介素-1拮抗剂是瘢痕缺陷愈合的治疗靶点。心脏干细胞释放的细胞因子在再生疗法中的作用,碎裂QRS波预测非透壁心肌瘢痕价值有限,交界区心肌瘢痕与室性心律失常密切相关。心肌瘢痕会引起心脏再同步化治疗无应答。
Scar formation is the most common method of repairing after myocardial infarction. The interaction between epicardium de- rived cell and bone marrow derived blood cell provide the cytoskeleton of scar formation. Additionally the combination of epicardium derived cell and bone marrow derived blood cell provide the cytoskeleton of scar formation, and phospholipase D1 can inhibit left ventricular remode- ling after infarction, reducing scar formation. The interleukin 1 antagonist is the therapeutic targets to prevent defective scar healing. The role of stem cells related to paracrine factor should be emphasized in the treatment of alternative therapy in myocardial regeneration therapy. The value of fragmented QRS wave in the prediction of non transmural cardiac scar is limited and border-zone infarcts are closely related to ven- tricular atThythmia. Myocardial scar is also related to the non-response of cardiac resynchronization therapy.
出处
《心血管病学进展》
CAS
2016年第1期66-69,共4页
Advances in Cardiovascular Diseases
关键词
心肌瘢痕
心脏再生
心律失常
心脏再同步化治疗
Myocardial scar
Cardiac regeneration
Cardiac arrhythmia
Cardiac resynchronization therapy
