摘要
目的探讨应用脱细胞异体真皮基质（acellulardermalMatrix，ADM）填塞治疗高位肛瘘的临床疗效。方法回顾性分析2013年9月-2015年3月就诊于新疆医科大学第一附属医院的52例高位肛瘘患者的临床资料，分为ADM治疗组和传统挂线对照组进行术后相关指标的分析。结果两组患者在性别（X2=0．087，P=0．768）、年龄（t=0．231，P=0．389）、民族（X2=0．391，P：0．532）、病程（t=0．316，P=0．690）、随访时间（t=0．512，P=0．209）上差异均无统计学意义，ADM组术后相关指标如肛门失禁（x2=5．532，P=0．019）、肛门畸形（X2=4．457，P=0．035）、术后疼痛时间（t=19．652，P=0．033）、术后愈合时间 （t=14．186，P=0．003）及生活质量评分（t=13．188，P=0．041）差异均有统计学意义（P〈0．05），明显优越于挂线组，但复发率（X2=4．127，P=0．042）较挂线组偏高。结论运用ADM治疗高位肛瘘具有微创、缩短愈合时间和保护肛门功能及外形等优势。
Objective To investigate the clinical curative effect of acellular dermal matrix( ADM) in the treatment of high anal fistula. Methods A retrospective analysis of clinical data of 52 cases of high anal fistula patients from September 2013 to March 2015 in First Teaching Hospital of Xinjiang Medical University was carried out,and analysis after operation of related index in ADM treatment group and traditional operation control group was perfomed. Results There were no statistical significances between the two groups in gender( χ2= 0. 087,P = 0. 768),age( t = 0. 231,P = 0. 389),ethnic( χ2= 0. 391,P = 0. 532),duration( t = 0. 316,P = 0. 690),follow- up time( t = 0. 512,P = 0. 209). There were statistical significances( P < 0. 05) in the related indicators in ADM group such as anal incontinence( χ2= 5. 532,P = 0. 019),anal malformation( χ2= 4. 457,P = 0. 035),postoperative pain( t = 19. 652,P =0. 033),healing time( t = 14. 186,P = 0. 003) and quality of life score( t = 13. 188,P = 0. 041). It was obviously superior to the quad hanging,but the recurrence rate( χ2= 4. 127,P = 0. 042) was higher than the quad hanging. Conclusion ADM has advantages in minimally invasive,shortening the healing time and protecting the anal function and forming in the treatment of high anal fistula.
出处
《医学研究杂志》
2016年第2期75-78,142,共5页
Journal of Medical Research
基金
新疆维吾尔自治区自然科学基金面上项目(2013211A077)
