摘要
目的:分析急性心肌梗死(AMI)患者胱抑素C(Cys-C)和白介素-6(IL-6)水平变化及对于远期预后的预测价值。方法:选取2012-06-2014-06我院心血管内科收治的AMI患者80例(AMI组),同时选取同期不稳定型心绞痛患者(不稳定型心绞痛组)和行常规健康体检志愿者(对照组)各80例。测定3组患者Cys-C和IL-6水平,比较AMI组患者不同时期Cys-C和IL-6变化,并比较不同Cys-C和IL-6水平的AMI患者主要不良心血管事件的发生率。结果:入组时Cys-C、IL-6、C-反应蛋白(CRP)、同型半胱氨酸(Hcy)水平为AMI组>不稳定型心绞痛组>对照组(P<0.05)。AMI患者入组后1d、3d、7d、1个月的Cys-C、IL-6逐渐下降(P<0.05),1个月后持续平稳(P>0.05)。随访期间Cys-C≥1.21 mg/L组和IL-6≥2.86 mg/L组的心肌梗死再发率高于Cys-C<1.21mg/L组和IL-6<2.86mg/L组(P<0.05,P<0.01)。入院时Cys-C、IL-6是AMI后主要不良心血管事件独立危险因素(P<0.05)。结论:Cys-C和IL-6对于AMI远期预后具有一定的预测意义。
Objective：To analyze the cystatin C（Cys-C）and interleukin-6（IL-6）levels and the predictive value of the long-term prognosis for acute myocardial infarction（AMI）.Method：Eighty cases of patients with AMI admited in our hospital cardiovascular internal medicine were analyzed from June 2012 to June 2014.At the same period 80 cases patients with unstable angina（unstable angina group）and 80 cases underwent routine healthy volunteers were selectedas the control group.Cys-C and IL-6levels were measured in patients with AMI.The changes of Cys-C and IL-6in different periods were compared.The major cardiac event rate of AMI patients with different Cys-C and IL-6levels was compared.Result：Cys-C,IL-6,CRP,Hcy levels of AMI group〉 unstable angina group 〉control group（P〈0.05）.Cys-C,IL-6in the AMI group decreased after 1d,3d,7d,1 month（P〈0.05）,which sustained 1month later（P〉0.05）.The recurrent myocardial infarction rate in Cys-C≥1.21mg/L group and IL-6≥2.86 mg/L were significantly higher than that in Cys-C1.21 mg/L group and IL-6 2.86mg/L group（P〈0.05,P 0.01）during the follow up.Cys-C,IL-6in Admission are the AMI independent risk factor for major adverse cardiac events（P〈0.05）.Conclusion：Cys-C and IL-6have some predictive significance for long-term prognosis of AMI.
出处
《临床急诊杂志》
CAS
2016年第1期44-47,共4页
Journal of Clinical Emergency
