摘要
目的:对联合应用乌司他丁以及奥曲肽治疗重症急性胰腺炎的临床效果进行评价。方法:将保山市人民医院2012年3月—2015年2月收治的120例重症急性胰腺炎患者按照随机数字表法分为观察组和对照组各60例。在常规治疗措施的基础上,对照组患者采用奥曲肽治疗,观察组患者在对照组的基础上联合应用乌司他丁治疗,比较临床疗效、腹痛腹胀缓解时间、血和尿淀粉酶恢复时间以及治疗后血和尿淀粉酶水平。结果:观察组患者的治疗有效率为91.67%(55/60),明显高于对照组的76.67%(46/60),差异有统计学意义(P<0.05);观察组患者的腹痛腹胀缓解时间、血和尿淀粉酶恢复时间均明显短于对照组,差异有统计学意义(P<0.05);治疗后,观察组患者的血淀粉酶以及尿淀粉酶水平明显优于对照组,差异有统计学意义(P<0.05)。结论:在综合治疗的基础上联合应用乌司他丁与奥曲肽治疗重症急性胰腺炎可较快改善患者的临床症状,降低血、尿淀粉酶水平,临床效果较好。
OBJECTIVE： To evaluate the clinical efficacy of ulinastatin combined with octreotide in treatment of severe acute pancreatitis. METHODS： 120 cases of severe acute pancreatitis admitted into People＇s Hospital of Baoshan from Mar. 2012 to Feb. 2015 were selected to be divided into observation group and control group via the random number table,with 60 cases in each. On the basis of routine treatment,the control group were treated with octreotide,and the observation group additionally received ulinastatin based on the control group. The clinical efficacy,the relief time of abdominal distention and abdominal pain,the restoration of blood and urinary amylase and level of blood and urinary amylase after treatment were compared. RESULTS： The total effective rate of the observation group was91. 67%（ 55 /60）,which was significantly higher than that of control group 76. 67%（ 46 /60）,with statistically significant difference（ P 〈0. 05）; the relief time of abdominal distention and abdominal pain and the restoration of blood and urinary amylase of observation group were significantly shorter than that of control group,with statistically significant difference（ P〈 0. 05）. After treatment,level of blood and urinary amylase in observation group was significantly better than that in control group,with statistically significant difference（ P〈 0. 05）. CONCLUSIONS： On the basis of comprehensive treatment,ulinastatin combined with octreotide in treatment of severe acute pancreatitis can rapidly improve patients＇ clinical symptoms,reduce blood and urine amylase levels and obtain good clinical effects.
出处
《中国医院用药评价与分析》
2016年第1期26-28,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
乌司他丁
奥曲肽
重症急性胰腺炎
临床疗效
Ulinastatin
Octreotide
Severe acute pancreatitis
Clinical efficacy
