摘要
目的探讨尿微量白蛋白(MA)、血β2微球蛋白(β2-MG)、α1微球蛋白(α1-MG)、胱抑素C(Cys-C)在小儿感染性肾早期损害的临床意义。方法包头市第八医院儿科2014年11月至2015年10月收治住院的急性感染患儿500例,通过检测尿MA、血β2-MG、α1-MG、Cys-C、尿素氮(BUN)、肌酐(Cr),选出尿MA、血β2-MG、α1-MG、Cys-C任一项超出正常参考值者作为肾早损研究对象,为观察组(108例)。同期选择门诊健康体检儿童70例为对照组。观察组以病原体培养、血常规、C反应蛋白、血清降钙素原、血清特异性抗体检查结合临床表现作为病原体诊断依据,确定其感染类型。统计肾早损观察组各指标异常检出率。结果观察组中尿MA、血β2-MG、α1-MG、Cys-C水平均高于对照组,差异有统计学意义(P<0.05);BUN、Cr与对照组比较差异无统计学意义(P>0.05)。血α1-MG在各感染组异常检出率最低;病毒感染组尿MA、血β2-MG、Cys-C异常检出率不同,差异有统计学意义(P<0.05),其中血β2-MG异常检出率最高;Cys-C在各种类型感染组中异常检出率比较差异无统计学意义(P>0.05)。结论血β2-MG诊断病毒感染性肾早期损害的敏感性最高,Cys-C的增高不受感染类型的限制,是各种类型感染性肾损害的良好诊断指标。
Objective To explore the clinical significance of urine MA,blood beta2-MG,alphal-MG, Cys-C in pediatric early renal damage. Methods Totally 500 cases of children with acute infection in Pediatrics Department of Baotou Eighth Hospital from November 2014 to October 2015 were included. Urine MA, blood beta2-MG,alphal-MG,Cys-C,BUN, and Cr were detected. Those with increase in any one item were selected as kidney dysfunction observation group（108 cases）. At the same time 70 healthy pediatric patients who came for regular check-ups at the OPD were selected as control group. Explore the clinical significance of urine MA, blood beta2-MG, alphal-MG,and Cys-C in different types of infectious early renal damage. Results In observation group,urine MA,blood beta2-MG,alphal-MG and Cys-C were all significantly higher than that of control group（P〈0.05） ;BUN and Cr had no statistically significant difference between the two groups（P〉0.05）. Blood alpha 1-MG in the infection group had the lowest detection rate. In virus infection group, the detection rate of urine MA, blood beta2-MG and Cys-C was different, the difference being statistically significant（P〈0.05）,in which the detection rate of blood beta2-MG was the highest. Cys-C＇s detection rate had no statistical difference in different infection groups. Conclusion This study suggests the blood beta2- MG is the most sensitive in diagnosis of virus infection with early renal damage. The increase of Cys-C is not limited by the type of infection,and is a good indicator of various types of infectious renal impairment.
出处
《中国中西医结合儿科学》
2016年第1期49-52,共4页
Chinese Pediatrics of Integrated Traditional and Western Medicine
