摘要
目的研究叉头框E1（FOXE1）基因上2个单核苷酸多态性（SNP）位点rs925489和rs1443434的基因多态性与中国汉族人群正常范围高促甲状腺素（TSH）水平的相关性。方法纳入TSH和甲状腺过氧化物酶抗体（TPOAb）均在正常范围内的受试者1400名。依据TSH、TPOAb水平分别将人群分为：正常范围高TSH组（H—TSH组，n=195）与正常范围TSH对照组（TSH对照组，n=1205）及正常范围高TPOAb组（H—TPOAb组，n=711）与正常范围低TPOAb组（L—TPOAb组，n=689）。采用全基因组芯片对所有受试者的这2个SNP位点进行基因分型。结果H-TSH组与TSH对照组的rs925489基因型分布及等位基因频率差异均有统计学意义（均P〈0．05），即H—TSH组基因型TT及等位基因T的频率均高于TSH对照组（89．75％对83．15％、94．62％对91．29％）。经性别、年龄和高密度脂蛋白胆固醇校正后，rs925489基因型分布与正常范围TSH水平显著相关（β=-0．232，P〈0．01）。而rs1443434基因型分布及等位基因频率在2个TSH组间或2个TPOAb组间无差异。结论FOXEl rs 925489基因多态性可能与中国汉族人群正常范围高TSH水平相关。
Objective To explore the correlation of the gene polymorphism of the two single nucleotide polymorphisms （ SNPs ） rs1443434 and rs925489 on forkhead box E1 （ FOXE1 ） with the high normal thyroid stimulating hormone （TSH） level in Chinese Han population. Methods 1 400 subjects with normal serum TSH and thyroid peroxidase antibody （TPOAb） levels were included. According to TSH or TPOAb levels, the subjects were divided into high normal TSH group （ H-TSH group, n = 195 ） and normal TSH control group （ TSH control group, n = 1 205 ） or high normal TPOAb group （ H-TPOAb group, n = 711 ） and low normal TPOAb group （ L-TPOAb group, n = 689 ） , respectively. The genotypes on the two SNPs of all the subjects were performed by whole-genome genotyping chips. Results There were significant differences in rs925489 genotypic distributions and allele frequencies between H-TSH group and TSH control group （ both P〈0.05 ）. The genotype TF and allele T in H-TSH group were significantly higher than those in TSH control group （89.75% vs 83.15% , 94.62% vs 91.29% ）. The normal TSH levels were positively associated with rs925489 genotypie distributions after adjustment for sex, age, and high density lipoprotein cholesterol （ P 〈 0. 01 ）. There were no significant differences in rs1443434 genotypic distributions and allele frequencies between two TSH groups or two TPOAb groups. Conclusion FOXE1 rs925489 gene polymorphism may be correlated with the high normal TSH level in Chinese Ftan population.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2016年第1期11-14,共4页
Chinese Journal of Endocrinology and Metabolism
基金
安徽省科技计划项目（12010402134）
