枸橼酸咖啡因治疗早产极低体重儿呼吸暂停的效果被引量：28

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摘要目的探讨枸橼酸咖啡因治疗早产极低体重儿呼吸暂停的疗效。方法选取新生儿重症监护室收治的体重<1 500 g的早产儿,随机分为观察组和对照组。两组在呼吸暂停发作后,予以弹足底、托背等触觉刺激,及时吸痰,保持呼吸道通畅,选择合适方式氧疗后仍反复发作者,加用药物治疗,观察组予以枸橼酸咖啡因,对照组予以氨茶碱。对比两组在治疗呼吸暂停的疗效及安全性,比较两组住院时间、氧疗时间及持续正压通气(CPAP)呼吸机辅助通气时间。结果观察组治疗呼吸暂停效果优于对照组,差异有统计学意义(P<0.01)。观察组在治疗期间心律失常、心动过速、喂养不耐受、尿量过多等不良反应发生情况明显少于对照组(P<0.05)。两组氧疗时间及CPAP呼吸机辅助通气时间比较,差异有统计学意义(P<0.05)。结论枸橼酸咖啡因治疗早产极低体重儿的呼吸暂停比氨茶碱更有优势,可作为新生儿重症监护室治疗呼吸暂停的优先选择。

作者林开颜蔡琍璇刘杨林明祥

机构地区广东省汕头市中心医院儿科

出处《广东医学》 CAS 北大核心 2016年第2期292-294,共3页 Guangdong Medical Journal

关键词咖啡因氨茶碱早产极低体重儿呼吸暂停

分类号 R174.4 [医药卫生—妇幼卫生保健]

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