摘要
目的探讨甲状腺激素治疗甲状腺结节的临床疗效。方法选择该院2014年1月至2015年3月甲状腺结节患者86例,分为对照组和观察组,每组各43例,对照组应用甲状腺片进行治疗,观察组应用左旋甲状腺素进行治疗。两组均连续治疗6个月,评估两组治疗效果,检测游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)及促甲状腺激素(TSH)水平,观察两组患者不良反应。结果观察组患者总有效率为83.72%(36/43),高于对照组的69.77%(30/43),差异有统计学意义(P<0.05);观察组患者治疗后结节直径为(9.82±0.91)mm,低于对照组(11.27±0.83)mm,两组治疗后均低于治疗前,差异有统计学意义(P<0.05);观察组和对照组治疗后FT3、FT4分别为(4.12±0.53)、(16.26±1.29)pmo/L和(4.01±0.49)、(15.30±1.21)pmo/L,均高于治疗前,差异有统计学意义(P<0.05);观察组患者治疗后TSH为(0.41±0.20)mIU/L,低于对照组治疗后(0.53±0.14)mIU/L,两组治疗后均低于治疗前,差异有统计学意义(P<0.05),观察组患者总不良反应率为9.30%(4/43),低于对照组20.93%(9/43),差异有统计学意义(P<0.05)。结论应用左旋甲状腺素治疗甲状腺结节具有较好的临床疗效,能够显著减小结节的大小,调节相关激素水平,并具有一定的安全性。
Objective To explore the clinical effect of thyroid hormone in the treatment of thyroid nodules.Methods Eightysix patients with thyroid nodules in our hospital from January 2014 to March 2015 were selected and randomly divided to the observation group and the control group,43 cases in each group.The control group was treated with the thyroid tablets treatment,while the observation group was treated with the levothyroxine treatment.The therapeutic effects of two groups were evaluated after 6-month continuous therapy.The levels of free triiodothyronine（FT3）,free thyroxine（FT4）and thyrotropic hormone（TSH）were detected.The adverse reactions were observed in the two groups.Results The total effective rate in the observation group was83.72%（36/43）,which was higher than 69.77%（30/43）in the control group,and the difference was statistically significant（P0.05）;the nodules diameters after treatment in the observation group was（9.82±0.91）mm,which was lower than（11.27±0.83）mm in the control group,which after treatment in the two groups were lower than before treatment,the difference was statistically significant（P0.05）.The levels of FT3 and FT4after treatment in the observation group and control group were（4.12±0.53）pmol/L,（16.26±1.29）pmo/L and（4.01±0.49）pmol/L,（15.30±1.21）pmo/L,respectively,which were higher than those before treatment,the differences were statistically significant（P0.05）;the TSH level after treatment in the observation group was（0.41±0.20）mIU/L,which was lower than（0.53±0.14）mIU/L in the control group,the difference was statistically significant（P0.05）.The occurrence rate of total adverse reactions in the observation group was 9.30%（4/43）,which was lower than20.93%（9/43）in the control group,the difference was statistically significant（P0.05）.Conclusion Levothyroxine for the treatment of thyroid nodules has better clinical efficacy,can significantly reduce the nodule size and regulates the related hormone levels,and has a certain security.
出处
《重庆医学》
CAS
北大核心
2016年第6期724-726,共3页
Chongqing medicine
基金
2013年浙江卫生厅一般项目(2013KYB299)
