摘要
目的总结花生枝叶在药物化学、药理和临床方面的研究。方法主要根据近30年来国内外公开发表的研究,对花生枝叶的基础和临床进行综述。结果发现花生枝叶提取物主要为有机酸类、油脂类、脂肪烷烃类、甾醇类、萜类、多酚类和挥发性芳樟醇类等物质;药理学研究证实其具有镇静安眠、改善学习和记忆力、抗动脉硬化、扩张脑动脉血管和增加心肌收缩力等作用,且在急性和慢性毒理学研究中未见异常;在临床研究中亦发现其有治疗失眠的作用。结论对花生枝叶治疗失眠研究较系统,但机制研究少,临床缺乏多中心双盲对照大样本研究;对于其药理学的其他作用,缺乏临床研究资料。
Objective To summarize early branches and leaves of Ara chis hypogaea L. basic and clinical research,which can provide the basis for further research and application. Methods It mainly based on published studies and reports on basic and clinical review of branches and leaves of Arachis hypogaea L at home and abroad in lately30 years. Results It was found that branches and leaves of Arachis hypogaea L extract mainly organic acids,oils,fats Anhui hydrocarbons,sterols,terpenoids,polyphenols and volatile substances such as linalool class; its pharmacological studies confirmed a sedative hypnotic,improve learning and memory,anti-atherosclerosis,dilatation of cerebral arteries and increase myocardial contractility,etc.,and there is no toxicity in acute and chronic; Which has also found that the effect of the treatment of insomnia in clinical studies. Conclusion branches and leaves of Arachis hypogaea L have a more systematic study in insomnia,but the mechanism is less research,clinical lack of multi-center double-blind controlled study of a large sample; others study on pharmacological effect is the lack of clinical research.
出处
《吉林中医药》
2016年第2期187-190,共4页
Jilin Journal of Chinese Medicine
基金
上海市卫生计划委员会资助项目:中医神志病建设项目(ZYSNXD-YL-YSZK021)
上海市财政资助项目"院内制剂落花安神合剂治疗不寐病的临床疗效和安全性再评价"(ZY3-JSFC-2-1014)
关键词
花生枝叶/药理学
花生枝叶/毒性
失眠症
落花生苷A
branches and leaves of Arachis hypogaea L / pharmacology
branches and leaves of Arachis hypogaea L / toxicology
insomnia
Groundnut glycosides A
