摘要
目的探讨子宫内膜组织中雌激素受体、转化生长因子-β1表达水平与宫腔粘连发病机制的相关性。方法采用前瞻性研究方法,对2013至2015年进行宫腔镜手术的宫腔粘连患者59例的转化生长因子-β1、雌激素受体水平进行检测,并与同期进行该手术但非该类疾病患者的相同指标进行比较分析。结果 TGF-β1及ER表达情况在各组差异均存在统计学意义(P<0.05),且组间对以上两项指标进行两两比较,差异有统计学意义(P<0.05);与此同时,该两项指标均与宫腔粘连的发生呈正相关(P<0.05),其相关系数分别为0.872、0.753。结论随着患者宫腔粘连程度加重,其TGF-β1及ER的表达水平有明显提高,与之具有较好的相关性,可作用临床诊断及治疗效果判断的指标。
Objective To investigate the correlation between expression levels of estrogen receptor （ER）, transforming growth factor -β1 （ TGF-β1 ） in endometrial tissues and pathogenesis of intrauterine adhesion. Methods The prospective study method was used to detect the expression ievels of ER, TGF-β1 in patients with intrauterine adhesion who underwent hysteroscope operation in our hospital from 2013 to 2015, and to compared these parameters with those of patients without intrauterine adhesion who underwent hysteroscope operation at the same period. Results There were significant differences in the expression levels of TGF-β1 and ER between the two groups and among groups （ P 〈 0.05 ） ,furthermore, the two indexes were positively correlated to the pathogenesis of intrauterine adhesion, and correlation coefficient of TGF-β1 and ER was 0. 872,0.753, respectively （ P 〈 0.05 ）. Conclusion The expression levels of TGF-β1 and ER in patients with intrauterine adhesion are obviously increased, with the aggravation of intrauterine adhesion degree, and there is a better correlation between them, therefore, which can be used as indexes for clinical diagnosis and evaluation of therapeuitic effects.
出处
《河北医药》
CAS
2016年第2期170-172,共3页
Hebei Medical Journal
基金
新疆医科大学科研创新基金(编号:XJC2013190)
关键词
宫腔粘连
转化生长因子-Β1
雌激素受体
intrauterine adhesions
transforming growth factor beta-1
estrogen receptor
