摘要
石蒜属植物富含生物碱类化学成分,并受到了国内外学者的广泛关注,按其分子骨架不同,主要分为7类,包括石蒜碱型、文殊兰型、加兰他敏型、水仙花碱型、水仙环素型、石蒜宁碱型或高石蒜碱型、猛他宁型。研究表明,石蒜属植物生物碱具有多种药理活性,对人乳腺癌MCF-7细胞、人早幼粒白血病HL-60细胞、转移性黑素瘤C8161细胞显示出较强的抗肿瘤活性;石蒜碱型生物碱对流感病毒、麻疹病毒、脊髓灰质炎病毒和SARS冠状病毒具有抑制作用;石蒜碱型生物碱和文殊兰型生物碱对恶性疟原虫具有抗疟活性;此外,石蒜碱还具有抗乙酰胆碱酯酶等多方面药理作用。石蒜属植物生物碱类化学成分的研究具有广泛的临床应用前景。
Recently, studies on Lycoris Herb. type alkaloids received the attention of scholars home and abroad. Lycoris Herb. type alkaloids can be devided into seven types according to their molecular structure, including lycorine type, crinine type, galanthamine type, tazettine type, narciclasine type, lycorenine type, homolycorine type, and montanine type. Researches have shown that LycorisHerb. type alkaloids possess multiple phamocology activities, such as strong antitumor activity on human breast cancer cell（MCF-7）, human leukemia cell（HL-60）; and strong inhibitory effect of flu virus, measles virus, polio virus, and SARS virus; Lycorine type and crinine type alkaloids have antimalaria effect; Besides, lycorine type has strong anti-acetylcholinesterase effect. In a word, lycorine type and lycoris type alkaloids carry multiple pharmacological effect and belong to promising substances.
出处
《中草药》
CAS
CSCD
北大核心
2016年第1期157-164,共8页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金资助项目(81274067)
黑龙江省自然科学基金资助项目(D201229)
