摘要
目的探讨甲状腺自身抗体(ATA)阳性患者的卵泡生成激素(FSH)、黄体生成素(LH)、雌二醇(E_2)水平。及其妊娠结局。方法回顾性分析2011年1月至2013年1月在兰州军区乌鲁木齐总医院优生优育门诊就诊的患者,其中98名ATA阳性,甲状腺功能正常且ATA阳性的育龄期女性列入阳性组,同时期门诊常规孕前检查者346人为对照组。结果 ATA阳性组的FSH、LH、E_2与对照组比较差异均无统计学意义(t值分别是0.550、0.685、1.079,均P>0.05)。ATA阳性组妊娠率为78.6%(77/92),低于对照组的87.9%(304/346),两组之间比较差异有统计学意义(X^2=5.413,P<0.05)。ATA阳性组的流产率为45.46%(35/77),高于对照组的23.7%(72/304),两组比较差异有统计学意义(X^2=14.417,P<0.01)。结论 ATA阳性患者与正常者之间卵巢储备功能无差异;ATA阳性患者的妊娠率明显低于正常者,但流产率高于正常者。
Objective To investigate FSH, LH and E2 levels in patients with positive thyroid autoantibodies （TAA） and their pregnancy outcomes.Methods Retrospective analysis was conducted on patients visiting Lanzhou Military Region General Hospital in Urumqi from January 2011 to January 2013, including 98 thyroid autoantibodies （TAA） positive women of childbearing age with normal thyroid function in positive group.At the same period 346 women taking routine examination were in control group .Results FSH, LH and E2 levels of two groups were not significantly different （t value was 0.550, 0.685 and 1.079, respectively, all P〉0.05）.The pregnancy rate was 78.6%（77/92） in positive group, which was significantly lower than 87.9% （304/346） in the control group （χ^2 =5.413, P〈0.05）.The abortion rate （45.46%, 35/77） of the positive group was higher than that （23.7%, 72/304） of the control group with significant difference （χ^2 =14.417,P〈0.01）.Conclusion Ovarian reserve function is not statistically different between TAA positive patients and normal controls .Pregnancy rate is obviously lower but abortion rate is higher in TAA positive patients than in controls .
出处
《中国妇幼健康研究》
2016年第1期33-35,共3页
Chinese Journal of Woman and Child Health Research
关键词
甲状腺自身抗体
卵巢储备功能
不孕
流产
thyroid autoantibodies （TAA）
ovarian reserve
infertility
abortion
