摘要
目的探讨新生儿糖尿病的诊治及其并发颅内出血的发病机制。方法分析1例新生儿糖尿病并发颅内出血的临床资料及复习相关文献。结果 KCNJ11及ABCC8基因突变相关性新生儿糖尿病患儿约占所有新生儿糖尿病(NDM)患儿的40%,占新生儿永久性糖尿病患儿(PNDM)的50%;新生儿糖尿病与颅内出血可能存在联系。结论较长新生儿糖尿病患儿可试验性应用格列本脲治疗;并认为颅内出血可能为渗出性出血,可能与分布于脑部神经元、血管内的ATP敏感钾通道(KATP)病变有关。
Objective To explore the diagnosis and treatment of neonatal diabetes mellitus （NDM） and the pathogenesis of it complicating intracranial hemorrhage .Methods Clinical data of a case of NDM complicating intracranial hemorrhage was analyzed and related literatures were reviewed.Results KCNJ11 and ABCC8 gene mutation associated NDM accounted for about 40% of all NDM, and it accounted for 50%of permanent neonatal diabetes mellitus （ PNDM ） . There could be connection between NDM and intracranial hemorrhage . Conclusion Older neonates with diabetes mellitus can use glibenclamide for trial treatment .Intracranial hemorrhage may be exudative hemorrhage, which could be related with ATP sensitive potassium channel （ KATP） lesion distributed in neurons and blood vessels in brain.
出处
《中国妇幼健康研究》
2016年第1期100-103,共4页
Chinese Journal of Woman and Child Health Research
关键词
新生儿糖尿病
颅内出血
诊治
发病机制
KCNJ11及ABCC8基因突变
neonatal diabetes meUitus （ NDM ）
intracranial hemorrhage
diagnosis and treatment
pathogenesis
KCNJ11 and ABCC8gene mutation
