摘要
目的:评价氟比洛芬酯联合碳酸利多卡因不同方式给药对腹腔镜妇科手术术后镇痛的效果。方法:选择行全麻下腹腔镜妇科手术90例患者,按随机数字表法将患者平均分成三组,对照1组手术完毕静脉注射100 mg氟比洛芬酯;对照2组手术完毕以100 m L 0.35%碳酸利多卡因进行盆腔冲洗,并以10 m L 0.87%碳酸利多卡因局部浸润腹部切口;观察组联合应用对照1组及对照2组的方法。比较各组患者术后1、4、8、12及24 h的视觉模拟评分(VAS)、术后镇痛药的用量及不良反应等。结果:术后1、4、8、12、24 h观察组VAS评分明显低于对照1组及对照2组,比较差异有统计学意义(P<0.05)。观察组术后无患者需要补充镇痛。三组术后恶心呕吐的发生率比较,差异无统计学意义(P>0.05)。结论:腹腔镜下进行妇科手术后给予氟比洛芬酯联用碳酸利多卡因不同给药方式(包括盆腔冲洗以及切口的局部浸润)较两者单独用药可使患者术后疼痛程度显著减轻,使术后继续使用镇痛药减少,且并未增加不良反应的发生率。
Objective： To compare the analgesia effect of mono or combination of intrapelvic irrigation and incision infiltration with lidocaine carbonate and intravenous flurbiprofen axetil after gynecological laparoscopy. Method： Ninety patients scheduled for gynecological laparoscopy under general anesthesia were divided into three groups accrording to random number table. Control group 1 received intravenous flurbiprofen axetil 100 mg after surgery, control group 2 received intrapelvic irrigation and abdominal wounds infiltration with 0.35% lidocaine carbonate 100 mL and 0.87% lidocaine carbonate 10 mL respectively, and observation group received the combination of the control group 1 and control group 2. VAS pain score was measured at 1, 4, 8, 12, 24 h after operation. Total analgesic requirement, the first passage of flatus and incidence of nausea and vomiting within 24 hours were recorded as well as side effects such as circumoral numbness, dizziness, and tinnitus. Result： VAS scores of the observation group was significantly lower than that of the control group 1 and control group 2 at 1, 4, 8, 12, 24 h after surgery, with significant differences （ P〈O.05 ） . No patient required repeated analgesia in the three groups. Conclusion： Combination of intravenous flurbiprofen axetil and intrapelvic irrigation （ including wound infiltration ） with lidocaine carbonatecan significantly reduce the pain intensity and analgesia requirement without＇increasing the incidence of nausea and vomiting compared with intravenous flurbiprofen axetil or intrapelvic irrigation alone after gynecological laparoscopy.
出处
《中国医学创新》
CAS
2016年第1期64-67,共4页
Medical Innovation of China
关键词
腹腔镜手术
术后镇痛
碳酸利多卡因
氟比洛芬酯
Laparoscopic surgery
Postoperative analgesia
Lidocaine
Flurbiprofen axetil
