1Sarris E G,Saif M W,Syrigos K N.The biological role of PI3K pathway in lung cancer[J].Pharmaceuticals(Basel),2012,5(11):1235-1264.
2Vanhaesebroeck B,Alessi D R.The PI3K-PDK1 connection:more than just a road to PKB[J].BIochem J,2000,346(3):561-576.
3Osaki M,Oshimura M,Ito H.PI3K-Akt pathway:its functions and alterations in human cancer[J].Apoptosis,2004,9(9):667-676.
4Rosen N,She Q B.AKT and cancer-is it all m TOR[J].Cancer Cell,2006,10(4):254-256.
5Mackay H J,Eisenhauer E A,Kamel-Reid S,et al.Molecular determinants of outcome with mammalian target of rapamycin inhibition in endometrial cancer[J].Cancer,2014,120(4):603-610.
6Ma X M,Blenis J.Molecular mechanisms of m TOR-mediated translational control[J].Nat Rev Mol cell Biol,2009,10(5):307-318.
7Tokunaga E,Oki E,Egashira A,et al.Deregulation of the Akt pathway in human cancer[J].Current cancer drug targets,2008,8(1):27-36.
8Xia Z,Gao T,Zong Y,et al.Evaluation of subchronic toxicity of GRD081,a dual PI3K/m TOR inhibitor,after 28-day repeated oral administration in Sprague-Dawley rats and beagle dogs[J].Food Chem Toxicol,2013,62(9):687-698.
9Oshiro N,Yoshino K,Hidaya S,et al.Dissociation of raptor from m TOR is a mechanism of rapamycin-induced inhibition of m TOR function[J].Genes Gells,2004,9(4):359-366.
10Jung C H,Ro S H,Cao J,et al.m TOR regulation of autophagy[J].Febs Lett,2010,584(7):1287-1295.
