摘要
表皮生长因子受体2(HER-2)是表皮生长因子受体家族的一名重要成员,对细胞生长、分化、凋亡的调节起着重要作用。随着针对胃癌HER-2癌基因靶向治疗的逐步明了,对临床医师预测患者的治疗结果、选择个体化的治疗方案提供真实可靠的依据。胃癌与结直肠癌同属消化道恶性肿瘤,期待HER-2在结直肠癌中像在胃癌中一样占据着重要的地位,本文综述了HER-2的概述、检测方法及与结直肠癌的关系。
Human epidermal growth factor receptor 2 （HER-2） is an important member of the epidermal growth factor receptor family, and plays an important role in the regulation of cell growth, differentiation and apoptosis. With better understanding of the important role of HER-2 in gastric cancer targeted therapy, clinicians could provide individual therapeutic strategies and could also predict clinical outcomes of patients. Since both gastric and colorectal cancers belong to malignant tumors of the digestive tract, we expect HER-2-targeted therapy to be effective in treating colorectal cancer as well. This paper is an overview of HER-2, detection methods and its association with colorectal cancer.
出处
《中华普外科手术学杂志（电子版）》
2016年第1期88-90,共3页
Chinese Journal of Operative Procedures of General Surgery(Electronic Edition)
关键词
结直肠肿瘤
受体
表皮生长因子
Colorectal neoplasms
Receptor, epidermal growth factor
