摘要
目的:探讨双歧杆菌与鼠李糖乳杆菌三联活菌制剂联合治疗小儿轮状病毒肠炎的临床疗效及对免疫功能的影响。方法:按照随机数字表法将120例轮状病毒肠炎患儿平均分为益生菌组和对照组,每组60例。对照组给予常规抗感染治疗,益生菌组在此基础上加用益生菌冻干粉治疗,比较两组患儿治疗3 d后临床疗效、临床症状消失时间以及治疗前后免疫功能指标,包括免疫球蛋白A(Ig A)、免疫球蛋白G(Ig G)、CD4+/CD8+的变化情况。结果:益生菌组临床治疗总有效率明显高于对照组,比较差异有统计学意义(P<0.05)。益生菌组患儿退热时间、呕吐消失时间、腹痛消失时间、止泻时间、粪常规恢复正常时间均明显低于对照组,比较差异有统计学意义(P<0.05)。两组患儿治疗后Ig A、Ig G、CD4+/CD8+水平较治疗前均明显升高,且益生菌组明显高于对照组,比较差异均有统计学意义(P<0.05)。结论:乳双歧杆菌、婴儿双歧杆菌、鼠李糖乳杆菌三联活菌制剂联合治疗小儿轮状病毒肠炎临床疗效显著,可在短时间内显著改善患儿临床症状和免疫功能指标,临床应用价值较高。
Objective： To explore the clinical effects for the patients with rotaviral enteritis by bifidobacterium combine with lactobacillus rhamnosus and the influence on the immune function. Method： According to random number table method, 120 patients with rotaviral enteritis were divided into probiotics group and control group, each group contained 60 cases. The control group was treated by routine anti- infection, on the basis of the control group, the probiotics group was treated by freeze-dried powder. After 3 days, clinical effect, clinical symptoms disappear time, and immune function （IgA, lgG, CD4＋/CD8＋） were compared between the two groups. Result： The total effective rate of the experiment group was higher than that of the control group, but fever subsidence time, vomiting disappear time, abdominal pain disappear time, time of checking diarrhea, dung conventional back to normal time of the experiment group was lower, the difference was statistically significant （ P〈0.05 ） . The level of IgA, IgG, CD4＋/CD8＋ after treatment of the two groups were both higher than before treatment, and the probiotics group were higher than the control group, the difference was statistically significant （P〈0.05） . Conclusion： It has distinct clinical curative effect for the patients with rotaviral enteritis by bifidobacterium combine with lactobacillus rhamnosus, it can improve the clinical symptoms, immune function, it has high value of clinical application.
出处
《中国医学创新》
CAS
2016年第6期59-62,共4页
Medical Innovation of China
关键词
乳双歧杆菌
婴儿双歧杆菌
鼠李糖乳杆菌
小儿轮状病毒肠炎
Bifidobacterium lactis
Bifidobacterium infantis
Lactobacillus rhamnosus
Infantile rotavirus enteritis
