摘要
目的应用Meta分析评价丹蒌片治疗冠心病病人的临床疗效。方法根据循证医学要求,分别检索了中国学术期刊(CNKI)、中国生物医学文献数据库(CBM)、万方数字资源系统和维普期刊资源整合平台上发表的文献、学位论文以及学术会议报告,共计16篇随机对照研究1 446例病人符合条件纳入分析,对照组予以常规治疗,试验组在常规治疗的基础上联合丹蒌片口服,选择心绞痛临床症状疗效、心电图疗效、总胆固醇以及低密度脂蛋白为效应指标,采用RevMan5.3进行统计学分析。结果 16篇研究中,1篇Jadad评分3分,2篇2分,剩余12篇均为1分,试验组相对于对照组心绞痛疗效RR=1.25,心电图改善RR=1.27,总胆固醇水平下降值WMD=1.04[-0.10,2.19],低密度脂蛋白水平下降值WMD=1.04[-0.10,2.19]。结论在常规治疗的基础上加用丹蒌片,可能对减少心绞痛发作和改善心电图有较好效果,但不一定能取得更好的降总胆固醇和低密度脂蛋白水平的效果,未来仍需要更多规范的大样本、多中心随机双盲对照试验的直接证据支持。
Objective In this study,we evaluated the clinical effect of Danlou tablets in coronary atherosclerotic disease by meta-analysis method.Methods In accordance with evidence-based medicine,we searched the following databases：China National Knowledge Infrastructure（CNKI）,China Biology Medicine disc（CBMdisc）,and Wanfang database.A total of 16 articles（1 446 patients）were included in our research.The control group was given routine treatment,and the Danlou group was given Danlou tablets in addition to routine treatment.The clinical outcomes,electrocardiogram（ECG）result,total cholesterol（TC）level,and low-density lipoprotein（LDL）level were chosen as evaluation factors.RevMan5.3 was applied for data processing and statistical analysis.Results Compared with the control group,the Danlou group presented an improvement in angina pectoris（RR=1.25[1.16,1.35]）and ECG（RR=1.27[1.11,1.44]）.And it showed no differences in D-value of TC（WMD=1.04[-0.10,2.19]）and LDL（WMD=1.04[-0.10 2.19]）.Conclusion Danlou tablets with the routine treatment could bring apositive short-term effect in reducing the onset of angina pectoris.However,more rigorously designed studies are needed to verify its effect in reducing TC and LDL levels.
出处
《中西医结合心脑血管病杂志》
2016年第3期241-247,共7页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
关键词
丹蒌片
冠心病
心绞痛
血脂
META分析
Danlou tablets
coronary atherosclerotic disease
angina pectoris
blood lipid
