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淋巴瘤相关巨噬细胞研究进展

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摘要 巨噬细胞是人体天然免疫系统的重要组分，通常源于外周血单核细胞，通过血循环到组织，具备吞噬、抗原提呈、细胞毒性、组织重塑等功能；部分巨噬细胞分布在淋巴瘤组织间质，是淋巴瘤微环境的主要成分，被称为淋巴瘤相关巨噬细胞（1ymphoma—associatedmacrophage，LAM）。LAM通过促进淋巴瘤细胞增殖、侵袭和血管新生等机制促进肿瘤生长；还可分泌白细胞介素（IL）10等细胞因子，诱导机体对肿瘤细胞的免疫耐受。
作者 王艳 邢莉民 邵宗鸿
机构地区 天津医科大学总医院血液科
出处 《中华医学杂志》 CAS CSCD 北大核心 2016年第8期669-672,共4页 National Medical Journal of China
基金 基金项目：天津市应用基础与前沿技术研究计划（15JCYBJC27300）
关键词 巨噬细胞 淋巴瘤 外周血单核细胞 天然免疫系统 组织重塑 白细胞介素 抗原提呈 细胞毒性
分类号 R733.1 [医药卫生—肿瘤]
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参考文献50

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中华医学杂志
2016年 第8期

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