摘要
乙型肝炎病毒(Hepatitis B virus,HBV)严重威胁人类健康,免疫紊乱是主要病理学机制。由于HBV不能自然感染小鼠,研究者试图创建HBV小鼠模型,以模拟HBV的免疫病理学过程。本文将介绍各种HBV小鼠模型的构建方法,包括HBV转基因技术、HBV病毒活体肝脏靶向转染技术以及HBV自然感染人源化小鼠技术等,同时还分析了各HBV小鼠模型的优缺点、利用这些模型所解决的一系列免疫学问题,以及该领域的发展展望。
Hepatitis B virus （HBV） threatens human Js health seriously, immune disorder is the main pathogenesis. HBV cannot naturally infect mouse liver, thus the researchers tried to established HBV mouse models to imitate the immunological pathogenesis of HBV infection. This review summarize various methods to establish HBV mouse models, including HBV transgenic technics, HBV in vivo liver-target transfection technics and HBV naturally infected humanized mouse technics etc. Their advantages, disadvantages and contributions to immunological studies were also analyzed, and the development of this area was also prospected.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2016年第2期145-153,共9页
Chinese Journal of Immunology
关键词
乙型肝炎病毒
小鼠模型
转基因
人源化
病毒免疫
Hepatitis B virus
Mouse model
Transgenic
Humanized mouse
Viral immunology
