摘要
脑创伤(traumatic brain injury,TBI)后血脑屏障(blood brain barrier,BBB)受损,脑内固有免疫细胞(小胶质细胞、星型胶质细胞等)和外周来源免疫细胞(巨噬/单核细胞、T细胞、中性粒细胞等)均参与到脑组织的炎症反应中,释放多种炎症因子、活性氧、化学诱导物,造成脑组织损伤,同时引发机体对免疫细胞的产生和功能的抑制性调节,即免疫抑制。本文就TBI后脑内炎症反应和外周免疫抑制方面的研究作一综述,旨在进一步了解其病理生理改变,为临床治疗提供理论依据。
The blood brain barrier（BBB）are damaged after traumatic brain injury（TBI）. Resident immune cells including microglia,astrocytes and periphery immune cells（monocytes/macrophages,T-cells,neutrophils,etc）are involved in the inflammation reaction of brain tissue. These cells release a variety of inflammatory factor,reactive oxygen species,chemical inducer,result in brain damage,and pull the trigger of the inhibitive regulation to depress the manufacture and feature of immune cells at the same time（immunosuppression）. This review describes the mechanism of brain inflammation and peripheral immunosuppression after TBI through the acquaintance of the pathophysiologic proceeding to provide advices and basis for clinical therapy.
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2016年第1期1-4,共4页
Journal of Chongqing Medical University
基金
国家自然科学基金资助项目(编号:81171090)
重庆市科委"基础科学与前沿技术研究专项"重点资助项目(编号:cstc2015jcyj B0226)
重庆市卫生局科研计划资助项目(编号:2009-2-264)
国家临床重点专科经费建设资助项目(编号:国卫办医函【2013】544)
关键词
脑创伤
炎症反应
免疫抑制
traumatic brain injury
inflammation response
immunosuppression
