摘要
目的探讨慢性肾脏疾病(CKD)患者血脂代谢异常与血压变异性的相关性。方法将适合标准的86例慢性肾脏疾病的患者纳入本研究,血脂正常的46例患者为对照组,而血脂异常的40例患者设为试验组。测量空腹时血清高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、总胆固醇、甘油三酯、尿酸、肌酐及24h尿蛋白定量。对所有患者行24h动态血压监测,对两组24h、日间、夜间收缩压标准差及变异系数和24h、日间、夜间舒张压标准差及变异系数进行对比分析,并检验与分析血压变异系数与血脂值的相关性。结果试验组24h、日间、夜间收缩压标准差及其对应的变异系数明显高于对照组,差异有统计学意义(P<0.05)。而两组的24h、日间、夜间舒张压标准差及其对应的变异系数差异无统计学意义(P>0.05)。试验组24h、日间及夜间收缩压变异系数均与TC呈正相关(r=0.24,P=0.032;r=0.18,P=0.044)。而对照组血压变异性指标与血脂无相关性(P>0.05)。结论 CKD合并高脂血症患者血压变异性与TC呈正相关,为了降低CKD患者血压变异性,减少心血管事件的发生,患者除了应尽早使血压达标外,还需尽早干预脂代谢使其恢复正常。
Objective To explore correlation of lipid abnormality and blood pressure variability of patients with chronic kidney disease（CKD）. Methods 86 qualified patients with chronic kidney disease were selected in the research. 46 patients with lipid normality were set as the control group and 40 patients with lipid abnormality were set as the experiment group. Serum high density lipoprotein cholesterol, low density lipoprotein cholesterol, total cholesterol, triglyceride, uric acid, creatinine and 24 h urinary protein were detected on an empty stomach. All patients were received ambulatory blood pressure monitoring. Systolic blood pressure standard deviation and coefficient of variation of 24 h, day and night and diastolic blood pressure standard deviation and coefficient of variation of 24 h, day and night of two groups were compared and analyzed. Correlation of coefficient of variation of blood pressure and lipid value was examined and analyzed. Results Systolic blood pressure standard deviation and coefficient of variation of 24 h, day and night of the experiment were significantly higher than those of the control group. The difference was statistical significant（P〈0.05）. Diastolic blood pressure standard deviation and coefficient of variation of 24 h, day and night of two groups had no statistical significant（P〉0.05）. Coefficient of variation of systolic blood pressure of 24 h, day and night of the experiment group was positively correlated to TC（r=0.24, P=0.032; r=0.18, P=0.044）. But blood pressure variability of the control group had no correlation with lipid（P〉0.05）. Conclusion Blood pressure variability of patients with CKD combined with hyperlipidemia is positively correlated to TC. In order to decrease blood pressure variability of CKD patients and reduce cardiovascular events, patients need to not only make blood pressure reach the standard but also intervene lipid metabolism to make it normal.
出处
《中国医药科学》
2015年第22期155-158,共4页
China Medicine And Pharmacy
关键词
肾脏疾病
血压变异性
血脂异常
心血管疾病
Kidney disease
Blood pressure variability
Lipid abnormality
Cardiovascular disease
