摘要
目的:研究射频热疗联合化疗方案在晚期恶性肿瘤患者中的治疗效果。方法:将本院2011年1月-2015年6月收治的76例晚期恶性肿瘤患者作为研究对象,按照入院顺序将其随机分为对照组和试验组,每组38例。对照组单纯采用常规化疗方案,试验组在此基础上联合采用射频热疗方案。观察两组患者的临床治疗效果,比较毒副作用和生活质量状况。结果:经治疗后,试验组患者的总有效率63.1%明显高于对照组的34.2%,差异有统计学意义(字2=6.372,P=0.012)。两组患者治疗期间的神经毒性、白细胞减少、胃肠道反应、肝功能损害的发生率比较差异均无统计学意义(P>0.05)。试验组患者出院时各项生活质量评分较入院时均明显改善,而对照组除食欲减退和呼吸困难外,其他各项生活质量评分较入院时均明显改善,且试验组各项生活质量评分均明显优于对照组,差异均有统计学意义(P<0.05)。结论:对于晚期恶性肿瘤患者而言,在常规化疗的基础上联合射频热疗效果更佳,能够提高治疗有效率,显著改善患者的生活质量,值得临床推广。
Objective： To study the therapeutic effect of radio frequency thermotherapy combined with chemotherapy in the treatment of patients with advanced malignant tumor.Method： Seventy-six patients with late malignant tumor in our hospital from January 2011 to June 2015 were selected as the research objects, they were randomly divided into the control group and the experimental group according to the order of admission, 38 cases in each group.The control group was given conventional chemotherapy regimens, the experimental group was given conventional chemotherapy regimens combined with radio frequency thermotherapy.The clinical therapeutic effect of the two groups was compared, and the side effects and quality of life between the two groups were compared. Result： After treatment, the total effective rate of the experimental group was 63.1%, which was significantly higher than 34.2% of the control group, the difference was statistically significant （ χ^2=6.372, P=0.012） . There were no statistically significant differences in the incidence rate of neurotoxicity, leukocyte reduction, gastrointestinal reaction and hepatic damage between the two groups （ P〉0.05 ） .The quality of life score of all indexes in the experimental group at discharge were significantly improved than on admission, in addition to loss of appetite and breathing difficulties, the quality of life score of other indexes in the control group at discharge were significantly improved than on admission, and quality of life score of all indexes in the experimental group were significantly better than the control group, the differences were statistically significant （ P〈0.05 ） . Conclusion： In patients with late malignant tumor, the effect of conventional chemotherapy combined with radio frequency thermotherapy is better, can improve the treatment efficiency, significantly improve the patients＇ quality of life, is worthy of clinical promotion.
出处
《中国医学创新》
CAS
2016年第5期143-146,共4页
Medical Innovation of China
关键词
恶性肿瘤
射频热疗
化疗
临床效果
毒副作用
Malignant tumor
Radio frequency thermotherapy
Chemotherapy
Clinical effect
Side effects
