摘要
目的观察缬沙坦联合二甲双胍对高血压合并代谢综合征(MS)患者血压及血液流变学的影响。方法将高血压合并MS患者137例随机分为治疗组68例及对照组69例。治疗组采用缬沙坦联合二甲双胍治疗,对照组采用缬沙坦治疗。两组均治疗12周,观察治疗前后患者血压、全血高切黏度、全血低切黏度、红细胞聚集指数、红细胞比容、血浆黏度以及糖脂代谢指标的变化情况。结果治疗组患者的血压、血液流变学参数与糖脂代谢指标、胰岛素抵抗水平均较治疗前明显下降或改善(P<0.05),且与对照组比较,差异有统计学意义(P<0.05)。结论缬沙坦与二甲双胍联用治疗高血压合并MS,能显著降低患者的血压并改善其血液流变学状态。
Objective To observe the effect of va1sartan and metformin to b1ood pressure and hemodynamics in hypertensive patients with metabo1ic syndrome. Methods A tota1 of 137 hypertensive patients with metabo1ic syndrome were random1y divided into treat-ment-group 68 cases and contro1-group 67 cases. The treatment-group was treated with va1sartan and metformin,whi1e,the contro1-group on1y with va1sartan. After 12 weeks of treatment,both groups of patients were observed with the changes in b1ood pressure,who1e b1ood viscosity（high shear and 1ow shear）,red ce11 assemb1ing index,hematocrit,p1asma viscosity and 1eve1s of b1ood g1ucose and serum 1ip-id. Results The treatment-group patients with b1ood pressure,who1e b1ood viscosity（high shear and 1ow shear）,red ce11 assemb1ing index,hematocrit,p1asma viscosity and 1eve1s of b1ood g1ucose and serum 1ipid,index of insu1in resistance were obvious1y dec1ined or improved compared with before treatment（P 〈 0. 05）,which were compared with contro1-group,the differences were a1so statistica11y significant（P 〈 0. 05）. Conclusion Treatment with va1sartan and metformin can remarkba1e1y reduce the 1eve1s of b1ood pressure and improve the hemodynamics situaiton in hypertensive patients with metabo1ic syndrome,which part1y due to their ro1es in regu1ating g1uco1ipid metabo1ism and re1ieving the situation of insu1in resistance.
出处
《临床军医杂志》
CAS
2015年第12期1236-1239,共4页
Clinical Journal of Medical Officers
