摘要
目的探讨血浆血小板活化因子乙酰水解酶(PAF-AH)对变应性皮肤血管炎的临床意义。方法采用PAF-AH活性检测试剂盒(酶水解底物显色法)测定变应性皮肤血管炎患者疾病过程中不同阶段及健康对照组的血浆PAF-AH活性。结果变应性皮肤血管炎患者病情活动期血浆PAF-AH活性明显低于健康对照组以及缓解期的酶活性,而患者缓解期的PAF-AH活性与健康对照组比较差异无统计学意义。结论血浆PAF-AH活性水平的波动与变应性皮肤血管炎病情的发生、发展、转归具有一定的关系。
Objective To investigate the levels of plasma PAF-AH in the pathogenesis of allergic cutaneous vasculitis. Methods Ac-tivity of plasma PAF-AH in patients with different stages of allergic cutaneous vasculitis and health control were detected by PAF-AH assay kit（ enzymatic hydrolysis of chromogenic substrate method） . Results The activity of plasma PAF-AH in patients with the active stage of disease was significantly lower than that of healthy controls and patients in remission stage, while there was no significant difference between that of patients in remission and healthy controls. Conclusion The fluctuation of the activity of plasma of PAF-AH has some relevance with the occurrence,development,prognosis in allergic cutaneous vasculitis. Deficiency of PAF-AH activity may be one of the pathogenesis of allergic cutaneous vasculitis.
出处
《临床军医杂志》
CAS
2015年第9期924-925,共2页
Clinical Journal of Medical Officers
