摘要
目的:研究胃癌中肿瘤相关巨噬细胞(TAM)与CCL5的表达及其相关性。方法:选择临床病理资料齐全的胃癌蜡块标本48例,癌旁组织作为对照,采用SP免疫组化法检测CD68和CCL5在胃癌组织及癌旁组织中的表达,并采用Spearman相关性统计方法对其相关性进行统计。结果:CD68和CCL5在胃癌组织中均呈阳性表达,且明显高于癌旁组织(P<0.01);CD68和CCL5与胃癌组织浸润深度、淋巴结转移情况、TNM分期情况及肿瘤分化程度均具有相关性(P<0.001),且胃癌中CD68和CCL5的表达程度呈正相关(P<0.01,r=0.759)。结论:CD68和CCL5对胃癌的发生、侵袭和转移起重要的促进作用,提示TAM分泌的CCL5可能促进胃癌侵袭转移。
Objective：To study the expression and correlation of tumor-associated macrophages （TAM） and CCL5 in ganstric cancer. Methods： 48 cases patients with completed clinical and pathological data of gastric cancer paraffin block specimens were select- ed. Cancer tissues and adjacent tissues were used as control, using SP immunohistochemical method to detect CD68 and CCL5 in gastric cancer tissues and adjacent tissues, and using the Spearman correlation statistics statistical methods for the correlation. Results： CD68 and CCL5 showed positive expression in gastric cancer tissue, significantly higher than those in the adjacent tissues （P〈0.01）, CD68 and CCL5 were related with gastric cancer invasion depth, lymph node metastasis, TNM stage and tumor differentiation（ P〈0. 001 ）. There was positive relation between the expression of CD68 and CCL5 in gastric cancer（ P〈0. 01, r = 0. 759 ）. Conclusion： CD68 and CCL5 played a driving role to the invasion and metastasis of gastric cancer occurrence, suggesting that the secretion CCL5 by TAM may promote the invasion and metastasis of gastric cancer.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2016年第1期74-78,共5页
Chinese Journal of Immunology
基金
河北省自然科学基金资助项目(No.H2015206376)
关键词
胃癌
TAM
CCL5
Ganstric cancer
Tumor associated macrophages （ TAM ）
CCL5
