摘要
目的:通过检测胃癌及癌前病变患者活检组织中血管内皮生长因子(VEGF)和突变型p53基因(mtp53)的表达,探讨VEGF和突变型p53基因在胃癌发生发展中的临床意义。方法:通过胃镜组织活检收集19例正常胃组织、22例肠上皮化生、47例胃肠黏膜不典型增生、54例胃癌样本,通过免疫组织化学染色检测组织中VEGF和mtp53的表达水平。结果:VEGF、mtp53的表达水平在正常胃组织,肠上皮化生,不典型增生以及胃癌中呈逐渐增高的规律。胃癌组织中VEGF和mtp53表达较正常胃组织、肠上皮化生组织显著增高(P<0.05),而与不典型增生组织差异无统计学意义(P>0.05)。结论:VEGF与突变型p53的异常表达可能与胃组织病变的恶化程度有关。
Objective： To detect precancerous lesions of gastric cancer and biopsy tissue vascular endothelial growth factor （VEGF） and mutant p53 gene（mtp53） expression, to explore the development of clinical significance of VEGF＇ and mutant p53 gene in gastric cancer. Methods： 19 Cases by endoscopic biopsies of normal gastric tissues ,22 cases of intestinal metaplasia,47 cases of gastro- intestinal mucosal dysplasia, 54 cases of gastric cancer samples by immunohistochemical staining to detect the expression levels of VEGF and mtp53＇s. Results： The expression levels of VEGF, mtp53 in normal gastric mucosa, intestinal metaplasia, dysplasia, and gradually increased gastric cancer was the law. mtp53 of VEGF expression in gastric carcinoma and compared with normal gastric tissue, intestinal metaplasia was significantly higher（ P〈0. 05 ）, but with atypical hyperplasia was no significant difference （P〉 0. 05 ）. Conclusion： The abnormal expression of VEGF and mutant p53 may be related to the degree of deterioration of the stomach tissue lesions related.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2016年第1期90-91,96,共3页
Chinese Journal of Immunology
基金
胃癌组织中VEGF及突变型p53基因表达及临床意义研究(No.2012GNS042-1)项目
