摘要
目的系统评价结肠癌完整结肠系膜切除术(CME)术后复发率和生存率情况。方法全面检索维普、CNKI、万方、Pub Med、Medline、OVID、Embase、Cochrane、ISI Web of Knowledge平台等近8年来公开发表的有关CME与传统结肠癌手术比较的文献,按标准严格筛选后,评估文献质量并提取完整数据资料,最后用Review Manager5.1软件进行系统评价。结果最终共纳入5篇非随机对照试验文献,共有病例1 804例,其中CME组558例,对照组1 246例。CME术后5年内复发率约为9.99%,Meta分析结果显示,CME组术后无瘤生存率、总体生存率高于传统手术组,差异有统计学意义(P<0.05)。结论 CME符合肿瘤学治疗原则,安全、可行,术后远期疗效确切,有望成为结肠癌全新的手术操作标准。
Objective To systemically assess the recurrence rate and survival rate of complete mesocolic excision（CME） for colon cancer. Methods The controlled studies which were related to the treatment of traditional surgery and CME for colon cancer and published in the last eight years were retrieved from the electronic databases （China National Knowledge Infrastructure, Wan.fang Database, PubMed, Medline, Ovid, Embase, Cochrane ISI Web of Knowledge, Cochrane Database of Systematic Reviews ）. With strictly screening according to the standard, the quality of studies was evaluated. Selective trials＇ data were analyzed by the Review Manager 5.1 software. Results A total of five nonrandomized clinical trials were finally included, involving a total of 1 804 patients in the research （558 patients in CME group and 1 246 patients in control group）. The 5-year postoperative recurrence rate of CME was 9. 99% on average. Mete-analysis showed that the postoperative disease-free survival and overall survival in CME group were significantly higher than those in the control group（ P 〈 0. 05 ）. Conclusion CME is safe and effective in accordance with the principles of oncology therapy and is expected to become a new standardized operation technique for colon cancer.
出处
《中国临床新医学》
2016年第2期108-113,共6页
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
基金
国家自然科学基金资助项目(编号:81360369)
广西卫计委科研课题(编号:Z2015362)
关键词
结肠癌
完整结肠系膜切除术
远期疗效
META分析
Colon cancer
Complete mesocolic excision
Long-term postoperative results
Meta-analysis
