摘要
心脏和肾脏的功能通过多种途径进行相互调控。心肾综合征(CRS)定义为由于心脏或肾脏急/慢性功能不全导致的另一器官功能的急/慢性失代偿状态。1型CRS以心功能急性恶化导致的急性肾损伤为特征。1型CRS患者病情更为复杂,住院期间的并发症发生风险更高,死亡率也更高。近年来许多研究开始关注1型CRS发病涉及的病理生理学过程,本综述的目的在于分析总结1型心肾综合征发病过程中涉及的血流动力学和非血流动力学因素,为1型CRS的防治工作提供理论参考。
The cardiorenal syndrome（CRS） is defined as a complex pathophysiological disorder of the heart and the kidneys whereby acute or chronic dysfunction in one organ may induce acute or chronic dysfunction in the other organ. In particular, CRS type 1 is characterized by a rapid worsening of the cardiac function leading to acute kidney injury. This clinical condition requires a more complex management given its more complicated hospital course and higher mortality. A lot of researches have emerged in the last years trying to explain the pathophysiology of CRS type 1 which remains in part poorly understood. This review primarily focused on the pathophysiologic mechanisms involved in this syndrome.
出处
《中华临床医师杂志（电子版）》
CAS
2016年第1期96-99,共4页
Chinese Journal of Clinicians(Electronic Edition)
关键词
心肾综合征
血流动力学
炎症
凋亡
交互作用
Cardiorenal syndrome
Hemodynamics
Inflammation
Apoptosis
Interaction
