摘要
骨巨细胞瘤(GCTB)是最常见的原发性骨肿瘤之一,具有侵袭性和潜在恶性转化的特点,手术切除是GCTB主要的治疗方法。目前随着分子生物学的相关研究进展,骨巨细胞瘤的治疗已进入综合治疗时代,其中RANKL拮抗剂与双膦酸盐在许多实体肿瘤的辅助治疗也正逐步成为研究的热点,尤其针对GCTB的辅助治疗降低术后复发率有明显效果。本文对RANK信号通路组成、转导及在GCTB发生发展过程中的影响以及相关药物辅助治疗的研究进展作简要综述。
GCT, one of the most common primary bone tumor, has the characteristics of invasive and potentially malignant transformation, surgical resection is the main treatment of GCB. With the current research progress in molecular biology, the treatment of giant cell tumor of bone has entered the era of comprehensive treatment, including RANKL antagonists and bisphosphonates in the adjuvant treatment of many solid tumors is also becoming hot, especially for GCTB adjuvant treatment of reducing the recurrence rate has a marked effect. This paper briefly reviewes the composition of RANK signaling pathway, transduction, influence in the development process and research progress of medica- tion-assisted therapy correlation
出处
《中国医药导报》
CAS
2016年第6期66-68,81,共4页
China Medical Herald
