摘要
肠道病毒71型（Enterovirus71，EV71）是小核糖核酸人肠道病毒A家族的一员，是引起小儿手足口病（hand—foot，and—mouth disease，HFMD）的主要病原体。树突状细胞（dendritic cells，DCs）是人类主要的抗原提呈细胞，在机体捕获、处理、提呈抗原，以及诱导特异性免疫应答过程中发挥至关重要的作用。目前对于EV71和DCs相互作用的形式和机制还不是很清楚，EV71感染的免疫逃逸机制也尚未明确。EV71与DCs最初和最直接的相互作用主要通过配体与细胞受体之间的结合来完成。细胞功能受体在参与DCs识别、捕获病毒，以及促进DCs的自噬与抗原提呈，启动机体免疫应答等方面均发挥重要作用。另一方面，病毒也可以利用与细胞受体的相互作用进行免疫逃逸。本文综合阐述了EV71与DCs等细胞上受体的相互作用，以期为EV71感染的研究提供参考。
Enterovirus 71 （ EV71 ） is one of the major causative agents of Hand, Foot and Mouth Disease （HFMD） , which belongs to the genus Enterovirus within the family Picomaviridae. Dendritic cells （DCs） are the main antigen presenting cells, which play a central role in the process of capturing, processing and presenting antigen, as well as in inducing specific immune response. By far, the interplay between EV71 and DCs is not very clear, and the mechanism of EV71 immune escape has not been revealed. The first interaction between EVT1 and DCs is accomplished by the binding of ligand to the receptor. Receptors of DCs contribute to the virus recognition, capture and presentation, and trigger cell autophagy and immune responses. On the other hand, virus can also escape from host immune responses by means of the interaction with the cell receptor. In this review, we summarize the current knowledge regarding cross-talk between EV71 and cell receptors on DCs and other human cells, providing a reference for the research of EV71 infection.
出处
《中华实验和临床病毒学杂志》
CAS
CSCD
2016年第1期100-103,共4页
Chinese Journal of Experimental and Clinical Virology
基金
国家自然科学基金（81301426）
校内重点项目（1208）
