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慢性肾脏病高磷血症肾损伤机制的研究进展 被引量：7

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摘要 高磷血症是慢性肾脏病（CKD）的特征之一。在CKD早期,肾功能下降,单个肾单位对磷的排泄增加使血磷水平维持在正常范围内。随着CKD进展,估算的肾小球滤过率（e GFR）进一步下降到25-30 ml/min,磷代谢失代偿,患者出现高磷血症-[1,2]。血磷升高会加快CKD的进展,并与慢性肾脏病患者死亡率密切相关-[3,4]。Lee等-[5]研究发现,在没有证据表明肾功能有异常的患者中,
作者 石敏 周莉 付平
机构地区 四川大学华西医院肾内科
出处 《中国中西医结合肾病杂志》 2016年第1期76-78,共3页 Chinese Journal of Integrated Traditional and Western Nephrology
关键词 高磷血症 肾脏病患者 肾损伤 肾小球滤过率 磷代谢 肾功能 内皮细胞 尿蛋白 肾脏纤维化 肾单位
分类号 R692 [医药卫生—泌尿科学]
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参考文献39

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同被引文献64

  • 1全国eGFR课题协作组.MDRD方程在我国慢性肾脏病患者中的改良和评估[J].中华肾脏病杂志,2006,22(10):589-595. 被引量：708
  • 2Melamed ML. Changes in serum caMum, phosphate, and PTH and the risk of death in incident dialysis patients:a longitudinal study. Kidney Int, 2006,70 ( 2 ) : 351 - 357.
  • 3Madsen KL. Stanniocalcin:a novel protein regulating calcium and phosphate transport across mammalian intestine. Am J Physiol, 1998,274( 1 ) :96 - 102.
  • 4Forsler I. Phosphate transporters in renal, gastrointestinal, and other tissues. Adv Chronic Kidney Dis ,2011,18 ( 2 ) :63 - 76.
  • 5Konno Y. Nuclear xenobiotic receptor PXR - null mouse exhibits hypophosphatemia and represses the Na/Pi - cotransporter SLC34A2. Pharmacogenet Genomics ,2010,20( 1 ) :9 - 17.
  • 6Schwab M. The dietaβ, histone deacetylase inhibitor sulforaphane induces human beta- defensin -2 in intestinal epithelial ceils. Immunology,2008,125 ( 2 ) : 241 - 251.
  • 7Kim B. Global metabolomics and targeted steroid profiling reveal that rifampin, a strong human PXR activator, alters endogenous urioa~ steroid markers. J Proleome Res, 2013,12 ( 3 ) : 1359 - 1368.
  • 8Sahbagh Y. Intestinal npt2b plays a major role in phosphate ab- sorption and homeostasis. J Am Soc Nephrol, 2009,20 ( 11 ) : 2348 - 2358.
  • 9Zhou C. The dietary isothiocyanate sullbraphane is an antagonist of the human steroid and xenobiotic nuclear receptor. Mol Phar- macol,2007,71 ( 1 ) :220 -229.
  • 10Mukherjee S, H Gangopadhyay, DK Das. Broccoli: a unique vegetable that protects mammalian hearts thruugh the redox cy- cling of the thioredoxin superfamily. J Agric Food Chem,2008, 56(2) :609 -617.

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中国中西医结合肾病杂志
2016年 第1期

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