摘要
目的：研究手足口病（hand,foot and mouth disease,HFMD）患儿血清硫化氢（hydrogen sulfide,H2 S）与白细胞介素（interleukin,IL）-6水平改变的意义。方法选择在我院住院治疗的92例HFMD 患儿为研究对象,根据病情,选择其中48例为重症 HFMD 组,44例为普通 HFMD 组,选择同期健康儿童46例为健康对照组。分别检测其血清 H2 S 及 IL-6水平。结果急性期：重症 HFMD 组与普通 HFMD 组血清 H2 S [（21.72±7.52）μmol /L、（31.86±8.41）μmol /L]水平均明显降低,IL-6[（131.33±17.82）ng /L、（95.48±15.07）ng /L]水平明显升高,与健康对照组[H2 S （55.76±7.80）μmol /L,IL-6（61.31±13.43）ng /L]比较差异有统计学意义（P ﹤0.01）；重症 HFMD 组与普通HFMD 组比较差异有统计学意义（P ﹤0.01）。恢复期：重症 HFMD 组血清 H2 S[（34.54±13.21）μmol /L]水平仍低于健康对照组,IL-6[（92.73±15.25）ng /L]水平仍高于健康对照组,差异有统计学意义（P ﹤0.01）。相关性分析显示：重症 HFMD 组与普通 HFMD 组血清 H2 S 与 IL-6水平之间均呈显著负相关（r ＝-0.31,P ﹤0.01；r ＝-0.45,P ﹤0.01）。结论 HFMD 患儿血清 H2 S 和 IL-6水平发生了改变,并且可作为重症 HFMD 患儿早期诊断的指标之一。
Objective To study the significance of level changes of serum hydrogen sulfide（H2 S） and interleukin-6（IL-6）in children with hand,foot and mouth disease（HFMD）.Methods Nity-two cases with HFMD were enrolled and divided into severe HFMD group（48 cases）and common HFMD group（44 cases）.Forty-six healthy children were enrolled as healthy control group.The serum H2 S and IL-6 were detected.Results Acute phase：compared to the healthy control group[H2 S（55.76 ±7.80）μmol /L,IL-6 （61.31 ±13.43）ng /L],the level of serum H2 S significantly reduced and the level of IL-6 significantly increased in severe HFMD group[H2 S（21.72 ±7.52）μmol /L;IL-6（131.33 ±17.82）ng /L]and common HFMD group[H2 S（31.86 ±8.41 ）μmol /L;IL-6（95.48±15.07）ng /L]（P ﹤0.01 ）,and there was signifi-cantly difference between the severe HFMD group and common HFMD group（P ﹤0.01 ）.Recovery phase：compared to the healthy control group,the serum H2 S level[（34.54 ±13.21 ）μmol /L]was lower and IL-6 [（92.73 ±15.25）ng /L]was higher in severe HFMD group（P ﹤0.01 ）.The serum H2 S level was negatively correlated with IL-6 in severe HFMD group and common HFMD group（r =-0.31 ,P ﹤0.01 ;r =-0.45, P ﹤0.01 ）.Conclusion The serum H2 S and IL-6 participate in the pathological process of HFMD,and the level change can be used as one of indicators of early diagnosis.
出处
《中国小儿急救医学》
CAS
2016年第2期92-95,共4页
Chinese Pediatric Emergency Medicine
关键词
手足口病
硫化氢
白细胞介素-6
Hand, foot and mouth disease
Hydrogen sulfide
Interleukin-6
