期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

微环境与肿瘤上皮间质转化的关系 被引量：1

Relationship of the epithelial-mesenchymal transition and tumor microenvironment
原文传递
导出
摘要 上皮-间质转化(EMT)是在各种因素影响下,上皮细胞转变成具有迁移能力的间质细胞的过程,在肿瘤的发生发展中具有重要作用。肿瘤微环境在恶性肿瘤进展过程中扮演着重要角色,本文综述了肿瘤微环境中的组织缺氧、炎性细胞、蛋白水解酶等对EMT的形成发挥的重要作用。 Epithelial-mesenchymal transition （EMT）is a process of transforming the epithelial cells into mesenchymal cells with migration ability,and has important effect on the tumor development. On the pres- ent paper, the important role of tissue hypoxia, inflammatory cells, cytolines and so on in tumor microenvi-ronment in EMT were reviewed.
作者 王兰香 贾永峰
机构地区 内蒙古医科大学基础医学院病理教研室
出处 《中国体视学与图像分析》 2015年第4期319-326,共8页 Chinese Journal of Stereology and Image Analysis
基金 国家自然科学基金(81260393) 教育部"春晖计划"合作科研项目(Z2012010) 内蒙古自治区应用技术研究与开发资金项目(No.kjt13sf03) 内蒙古自治区高等学校青年科技英才支持计划(NJYT-14-A11)
关键词 上皮间质转化 肿瘤微环境 肿瘤细胞 蛋白水解酶 epithelial-mesenchymal transition tumor microenvironment tumor cell proteolytic enzymes
分类号 R730.2 [医药卫生—肿瘤]
  • 相关文献

参考文献34

  • 1Foroni C, Broggini M, Generali D, et al. Epithelial-mes- enchymal transition and breast cancer: role, molecularmechanisms and clinical impact [ J ] . Cancer Treatment Reviews, 2012, 38(6): 689-697.
  • 2Thiery J P. Epithelial-mesenchymal transition in develop- ment and pathologies[ J]. Current Opinion in Cell Biolo- gy, 2003, 15(6) :740 -746.
  • 3Guarino M. Epithelial-mesenchymal transition and tumor invasion[J]. The International Journal of Biochemistry & Cell Biology, 2007, 39 (12) : 2153 - 2160.
  • 4Talbot L J, Bhattacharya S D, Kuo P C. Epithelial-mes- enchymal transition, the tumor microenvironment, and metastatic behavior of epithelial malignancies [ J~. Inter- national Journal of Biochemistry and Molecular Biology, 2012, 3(2) : 117 -136.
  • 5Jing Y, Han Z, Zhang S, et al. Epithelial-Mesenchymal transition in tumor micro-environment[ J]. Cell & Biosci- ence, 2011, 1: 29.
  • 6Cockman M E, Masson N, Mole D R, et al. ducible factor-c~ binding and ubiquitylation Hippel-Lindau tumor suppressor protein [ J ] Hypoxia in- by the yon Journal of Biological Chemistry, 2000, 275 (33) : 25733 - 25741.
  • 7Semenza G L, Wang G L. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for tran- scriptional activation[ J]. Molecular and Cellular Biology, 1992, 12(12) : 5447 -5454.
  • 8Yoo Y G, Christensen J, Gu J, et tumor hypoxia to confer a perpetual type for malignant progression [ J ] 2011, 4(178) :pt4. al. HIF-lct mediates mesenchymal pheno- Science Signaling,.
  • 9Yang M H, Wu M Z, Chiou S H, et al. of twist by HIF-lapromotes metastasis[ Jl ology, 2008, 10(3) :295 -305. Direct regulation Nature Cell Bi-.
  • 10Chen J, Imanaka N, Griffin J D. Hypoxia potentiates notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and in- vasion [ J ]. British Journal of Cancer, 2010, 102 ( 2 ) : 351 - 360.

二级参考文献29

  • 1Minal Garg.Epithelial-mesenchymal transition- activating transcription factors- multifunctional regulators in cancer[J].World Journal of Stem Cells,2013,5(4):188-195. 被引量：27
  • 2阮黎,张旭,马鑫,郑诗,李宏召,李龙承,叶章群.膀胱移行细胞癌E-钙粘连素基因启动子C/A单核苷酸多态性与肿瘤复发的关系[J].中华实验外科杂志,2005,22(1):9-11. 被引量：14
  • 3杨玉琮,李旭,陈葳.免疫相关基因在同一膀胱癌亚克隆细胞株中的差异表达[J].细胞与分子免疫学杂志,2006,22(5):625-627. 被引量：4
  • 4Said NA,Williams ED.Growth factors in induction of epithelial-mes-enchymal transition and metastasis.Cells Tissues Organs,2011,193:85-97.
  • 5Baumgart E,Cohen MS,Silva Neto B,et al.Identification and prognos-tic significance of an epithelial-mesenchymal transition expression pro-file in human bladder tumors.Clin Cancer Res,2007,13:1685-1694.
  • 6Candido J, Hagemann T. Cancer related inflammalion [J]. J Clin Immunol, 2013,33 Suppl 1 :S79-84.
  • 7Thiery JP. Epithelial-mesenchymal transitions in tumour progression[J]. Nat Rev Cancer, 2002,2(6) :442-454.
  • 8Wu Y, Zhou BP. TNF-alpha/NF-kappaB/Snail pathway in cancer cell migration and invasion[J]. Br J Cancer, 2010, 102(4) :639-644.
  • 9Gao D, Vahdat LT, Wong S, et al. Microenvironmental regulation of epithelial-mesenchymal transitions in cancer[J]. Cancer Res, 2012,72(19) :4883-4889.
  • 10Chen XF, Zhang HJ, Wang HB, et al. Transforming growth factor-β1 induces epithelial-to-mesenchymal transition in human lung cancer ceils via PI3K/Akt and MEK/Erkl/2 signaling pathways[J]. Mol Biol Rep, 2012, 39(4):3549- 3556.

共引文献39

同被引文献15

引证文献1

中国体视学与图像分析
2015年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部