摘要
目的:探讨马来酸依那普利叶酸片对H型高血压患者血压及血清Hcy水平的影响。方法:117例H型高血压患者随机分为A、B、C 3组,每组39例。A组给予复方制剂马来酸依那普利叶酸片10 mg/0.8 mg/d;B组给予马来酸依那普利片10 mg/d+叶酸片0.8 mg/d;C组仅给予马来酸依那普利片10 mg/d。3组均连续服用12个月。观察治疗前及治疗后第3、6、9、12个月3组患者血压及同型半胱氨酸(Hcy)水平的变化。结果:治疗后第3、6、9、12个月,3组收缩压、舒张压均较治疗前显著降低(P<0.01),但3组间比较差异均无统计学意义(P>0.05)。治疗后第6、9、12个月,A、B两组Hcy水平较治疗前明显降低(P<0.01),且显著低于C组(P<0.01);治疗后第12个月,A组Hcy水平低于B组,差异有统计学意义(P<0.05)。A、C组脑卒中发生率比较差异有统计学意义(P<0.05)。结论:马来酸依那普利叶酸片能有效控制H型高血压患者的血压,降低Hcy水平,降低此类患者脑卒中的发生率。
Objective： To explore the influence of Enalapril Maleate-Folate Tablets on blood pressure and serum Hcy level in patients with H-type hypertension. Methods： A total of 117 patients with H-type hypertension were randomly divided into group A,B and C,39 cases in each group. Patients in group A were treated with compound preparation（ Enalapril Maleate-Folate Tablets,10 mg /0. 8 mg / d）,group B treated with 10 mg / d Enalapril Maleate Tablets plus 0. 8 mg / d Folic Acid Tablets,and group C treated with 10 mg / d Enalapril Maleate Tablets. Three groups were continuously treated for 12 monthly. The changes of blood pressure and Hcy level of patients were recorded before treatment and after treatment 3,6,9,12 months. Results： Systolic pressure and diastolic pressure decreased more significantly after treatment 3,6,9,12 months,but with no statistical significance among groups（ P〉 0. 05）. Hcy level of group A and B declined obviously than that of before treatment（ P〈 0. 01） and was lower than that of group C（ P 〈0. 01） after treatment 6,9,12 months. Hcy level of group A was lower than that of group B after treatment 12 months（ P〈 0. 05）. There was statistical difference in the occurrence of stroke between group A and C（ P〈 0. 05）. Conclusion： Enalapril Maleate-Folate Tablets can effectively control the blood pressure,decrease the Hcy level and reduce the occurrence of stroke of patients with H-type hypertension.
出处
《川北医学院学报》
CAS
2016年第1期88-90,100,共4页
Journal of North Sichuan Medical College
