摘要
目的:探讨姜黄素对癫痫大鼠认知功能障碍的预防作用及机制。方法:选取45只癫痫大鼠随机分为姜黄素干预组(n=15)、单纯致痫组(n=15)和正常对照组(n=15),检测其学习记忆功能情况以及超氧化物歧化酶(SOD)、谷胱甘肽(GSH)、谷胱甘肽过氧化物酶(GSH-Px)和丙二醛(MDA)水平。结果:单纯致痫组大鼠寻找平台潜伏期长于正常对照组(P<0.05);姜黄素干预组大鼠寻找平台潜伏期短于单纯致痫组(P<0.05)。单纯致痫组大鼠脑组织的SOD、GSH、GSH-Px水平低于正常对照组(P<0.05),而MDA水平明显较高(P<0.05);姜黄素干预组大鼠脑组织的SOD、GSH、GSH-Px水平高于单纯致痫组(P<0.05);不同浓度姜黄素干预组大鼠在寻找平台潜伏期以及各项指标水平组间比较,差异无统计学意义(P>0.05)。结论:姜黄素能够明显减轻癫痫状态下的大鼠认知功能障碍。
Objective TTo investigate the preventive effect and mechanism of curcumin on cognitive dysfunction in rats with epilepsy. Methods 45 rats were randomly divided into curcumin intervention group （n=15）, n=15 and normal control group （n=15）, to detect the learning and memory function and superoxide dismutase （SOD）, glutathione （GSH）, glutathione peroxidase （GSH-Px） and malondialdehyde （MDA） levels. Results the search platform of rats with epilepsy was longer than that of normal control group （P 〈 0.05）. The latency of the search platform of the curcumin intervention group was shorter than that of the simple induced epilepsy group （P 〈 0.05）. The levels of SOD, GSH and GSH-Px were lower than the normal control group （P 〈 0.05）, but the MDA level was significantly higher （P 〈 0.05）. The SOD, GSH and GSH-Px levels were higher than those in the control group （P 〈 0.05）. There was no significant difference between the two groups （P 〉 0.05）. Conclusion curcumin can significantly reduce cognitive dysfunction in rats with epilepsy.
出处
《深圳中西医结合杂志》
2016年第2期1-3,共3页
Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
基金
广东省医学科学技术研究基金项目资助课题(A2015335)
关键词
姜黄素
癫痫大鼠
认知功能障碍
Curcumin
Rats with epilepsy
Cognitive dysfunction
