摘要
目的探讨武汉市子宫内膜癌及癌前病变的危险因素。方法选取2012年3月-2015年3月武汉市接受宫腔镜+诊刮术+子宫内膜细胞学检查的女性678例作为研究对象,对比子宫内膜细胞学检查和组织病理学检测的结果。应用Logistic回归分析影响子宫内膜细胞学和组织病理学诊断结果的相关因素。结果子宫内膜细胞学诊断结果显示,子宫内膜癌56例(8.5%)、子宫内膜非典型性增生82例(12.4%);组织病理学诊断结果显示,子宫内膜癌52例(8.2%)、子宫内膜非典型性增生79例(12.4%);诊断结果基本相同。Logistic回归分析发现,子宫内膜细胞学诊断中子宫内膜癌及癌前病变的危险因素为绝经、糖尿病、家族恶性肿瘤史、高血压、年龄≥40岁和体重指数≥23 kg/m^2,独立危险因素为年龄≥40岁、体重指数≥23 kg/m^2。Logistic回归分析发现,组织病理学诊断中子宫内膜癌及癌前病变的危险因素为绝经、糖尿病、家族恶性肿瘤史、高血压、年龄≥40岁、体重指数≥25 kg/m^2及接触过毒性放射线,独立危险因素为糖尿病、家族恶性肿瘤史、年龄≥40岁及体重指数≥25 kg/m^2。结论与组织病理学检测方法相比,子宫内膜细胞学检查在子宫内膜癌及癌前病变的筛查中均具有更高的应用价值。有家族恶性肿瘤史、体重指数偏高、患有糖尿病与高血压等慢性疾病、年龄≥40岁的女性需要定时进行子宫内膜癌及癌前病变的筛查工作,子宫内膜细胞学和组织病理学诊断的相关危险因素相差不大。
Objective To explore the risk factors of endometrial carcinoma and precancerous lesions in Wuhan city. Methods A total of 678 women receiving hysteroscopy,curettage,and endometrial cytology test in Wuhan from March 2012 to March 2015 were selected,the results of endometrial cytology test and histopathological examination were compared. Logistic regression analysis was used to analyze the related influencing factors of diagnostic results of endometrial cytology test and histopathological examination. Results Endometrial cytology test showed that endometrial carcinoma in 56 cases（ 8. 5%） and endometrial atypical hyperplasia in 82 cases（ 12. 4%）. Histopathological examination showed that endometrial carcinoma in 52 cases（ 8. 2%） and endometrial atypical hyperplasia in 79 cases（ 12. 4%）. The diagnostic results were basically the same. Logistic regression analysis showed that the risk factors of endometrial carcinoma and precancerous lesions diagnosed by endometrial cytology test included menopause,diabetes,family malignant tumor history,hypertension,≥40 years,and body mass index（ BMI） ≥23 kg / m^2; the independent risk factors included ≥40 years and BMI≥23 kg/m^2. Logistic regression analysis showed that the risk factors of endometrial carcinoma and precancerous lesions diagnosed by histopathological examination included menopause,diabetes,family malignant tumor history,hypertension,≥40 years,BMI≥23 kg / m^2,and exposure to toxic radiation; the independent risk factors included diabetes,family history of malignancy,≥40 years,and BMI≥23 kg / m^2. Conclusion Compared with histopathological examination,endometrial cytology test in endometrial carcinoma and precancerous lesions screening has a higher application value.The women having familial malignant tumor history,high BMI,diabetes,hypertension,other chronic diseases,and ≥40 years need endometrial carcinoma and precancerous lesions screening regularly. The risk factors of endometrial cytology test and histopathological examination are similar.
出处
《中国妇幼保健》
CAS
2016年第6期1139-1142,共4页
Maternal and Child Health Care of China
基金
湖北省自然科学基金(2014CFB305)
关键词
子宫内膜癌
癌前病变
诊断
危险因素
Endometrial carcinoma
Precancerous lesion
Diagnosis
Risk factor
