摘要
目的:分析贝伐珠单抗致胃肠道穿孔(gastrointestinal perforation,GIP)的发生规律及特点,为安全用药提供参考。方法:检索2004年至2015年3月国内外学术期刊收载的贝伐珠单抗致GIP文献进行分析。结果:17例不良反应中,男性9例,女性8例,年龄≥65岁的老年患者7例(41.18%);17例GIP患者中,发生在前15周疗程内有13例(76.47%)。有7例采用非手术保守治疗,10例采取手术治疗,死亡7例。结论:临床医师应了解贝伐珠单抗致GIP的规律和特点,加强用药监测,以便及时发现和处理GIP。
Objective: To analyze the general patterns and characteristics of gastrointestinal perforation( GIP) induced by bevacizumab,providing a reference for clinical medication. Methods: Bevacizumab-induced GIP reported from 2004 to March 2015 via searching CNKI,VIP and Pubmed were collected and analyzed statistically. Results: Totally 17 patients of GIP caused by bevacizumab were collected,including 9 men and 8 women. Patients over the age of 65 years showed the higher incidence( n = 7,41. 18%). In 17 patients with GIP,13( 76. 47%) developed within the first 15 weeks of the treatment. There were 7 patients receiving non-surgical conservative treatment and 10 receiving surgical treatment. Of the 17 GIP patients,7 patients died. Conclusion: Clinicians should be aware of rules and characteristics of GIP induced by bevacizumab,and tighten monitoring its using to detect and deal with GIP.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2016年第5期594-596,共3页
Chinese Journal of New Drugs
关键词
贝伐珠单抗
胃肠道穿孔
文献分析
bevacizumab
gastrointestinal perforation
literature analysis