摘要
[目的]对黄芪多糖治疗哮喘的机制研究进行展望。[方法]通过对国内外关于中药单体黄芪多糖的文献进行检索,将黄芪多糖对IL-4、IL-10等细胞因子及Th1/Th2平衡等在炎性浸润方面、平滑肌肌动蛋白及气道粘液等气道重塑方面、哮喘相关基因等方面的研究进行总结。[结果]黄芪多糖能从以下几方面改善哮喘气道炎症:抑制EOS的活化及减少EOS浸润,调节Th1/Th2失衡,使Th0细胞向Th1细胞分化,以及抑制炎症因子的释放等;从以下几方面减轻气道重塑:降低气道高反应性,减轻支气管周围嗜酸性粒细胞浸润及诱导的气道平滑肌细胞α-SMA的高表达等。[结论]黄芪多糖对哮喘基因的影响的研究将为治疗哮喘的机制研究奠定基础,为中药单体研究提供新的思路。
[Objective] The mechanism of astragalus polysaccharides treatment of asthma was discussed. [Methods]Through the domestic and foreign about traditional Chinese medicine monomer astragalus polysaccharide on IL-4, IL-10 and other cytokines and inflammatory infiltrates aspects such as the Thl/ Th2 balance, smooth muscle actin and airway mucus in the airway remodeling and asthma related gene research literature summary. [Results] Improve airway inflammation astragalus polysaccharides from activation and inhibition EOS EOS infiltration reduction, regulating Thl/Th2 imbalance, so ThO cells to Thl cell differentiation, and inhibiting the release of inflammatory cytokines and other aspects, APS can reduce airway hyper-responsiveness mitigate aspects peribronchial infiltration of eosinophils and airway smooth muscle cells induced by α-SMA expression and other high alleviate airway remodeling. [Conclusion] The influence of astragalus polysaccharide on asthma gene research will lay the basis for study of the mechanism of treatment of asthma, monomer research provides new ideas for traditional Chinese medicine.
出处
《浙江中医药大学学报》
CAS
2016年第1期72-74,共3页
Journal of Zhejiang Chinese Medical University
基金
国家自然科学基金项目(81173299)
国家重点学科课题(EZK2012005)
江苏省研究生培养创新工程项目课题(CXLX13-584)~~
关键词
黄芪多糖
哮喘基因
炎症
气道重塑
进展
综述
Astragalus Polysaccharide
asthma gene
inflammation
airway remodeling
review
