摘要
[目的]探讨乳果糖口服液联合微生态制剂(美常安)治疗便秘型肠易激综合征(IBS-C)的临床疗效。[方法]IBS-C患者231例,随机分为联合治疗组(71例)、乳果糖组(84例)和莫沙必利组(76例),疗程均为8周。记录及评价3组患者治疗前后的排便次数、大便性状及便秘程度。[结果]治疗后,排便次数及大便Bristol评分:3组均较治疗前明显提高,且治疗前后3组之间两两相比较差异无统计学意义。便秘程度的AGACHAN得分:治疗前3组之间比较差异无统计学意义;治疗后,3组均较治疗前明显降低,且联合治疗组明显低于乳果糖组、莫沙必利组,差异有统计学意义(P<0.05),而乳果糖组与莫沙必利组治疗后评分差异无统计学意义(P>0.05)。[结论]乳果糖联合益生菌可明显改善IBS-C患者便秘程度,但在改善大便性状及大便次数方面与单用乳果糖、莫沙必利的疗效无差别。
[Objective]To evaluate the clinical efficacy and feasibility on constipation-dominant irritable bowel syndrome（IBS-C）treated with lactulose oral solution combined with probiotics. [Methods]The totals of 231 patients diagnosed as IBS-C were randomly divided into three groups, which were the combination therapy group, lactulose and mosapride group. Treatment lasted 8 weeks. Main outcomes assessment in- cluded with frequency of bowel movements,Bristol score and AGACHAN score of constipation intensity of patients before and after treatment, l-Results]The frequency of bowel movements and Bristol score were im- proved significantly in three groups after treatment comparing with which before treatment （P〈0.05）, while were no significant difference between three groups before and after treatment （P 〉 0. 05）. Before treatment,the AGACHAN score of constipation intensity in the three groups were not significantly differ- ent（P〉0.05）. The AGACHAN score after treatment were lower than that before the treatment,and the difference was statistically significant（P〈0.05）. The AGACHAN score after treatment in combined treatMent group was lower than those in lactulose group and mosapride group, and the difference was statistically significant（P〈0.05）. The difference between lactulose group and mosapride group was not statistically significant（P 〈 0.05 ）. [Conclusion] Lactulose combined probiotics （Meichangan） can significantly improve constipation-predominant irritable bowel syndrome patients with constipation intensity, without higher frequency of bowel movements and Bristol score than lactulose or mosapride alone.
出处
《临床消化病杂志》
2016年第1期32-35,共4页
Chinese Journal of Clinical Gastroenterology
关键词
便秘型肠易激综合征
乳果糖
益生菌
便秘
constipation-dominant irritable bowel syndrome
lactulose ~ probiotics
constipation
