右美托咪啶预防妇科腹腔镜手术患者全麻苏醒期心血管反应的临床观察被引量：11

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摘要目的评价右美托咪啶对预防妇科腹腔镜手术患者拔管时心血管反应的有效性。方法择期60例妇科手术患者。采用随机数字表法,将其随机分为对照组(C组)和右美托咪啶组(D组),每组30例。2组均采用全凭静脉麻醉,D组患者在手术结束前30 min静脉泵注0.5μg/kg的右美托咪啶,药物需要静脉输注10 min。C组输注0.9%氯化钠溶液。手术结束缝皮前停用静脉麻醉药,手控诱导呼吸。分别于入室后诱导前(T0)、拔管后1 min(T1)、3 min(T2)、5 min(T3)时记录MAP、HR,颈内静脉采血,于以上各时点测定血浆肾上腺素(E)、去甲肾上腺素(NE)浓度。结果与T0时比较,2组患者在T1、T2时MAP、HR有不同程度的升高,C组较D组相比明显升高(P<0.05);D组与拔管前比较差异无统计学意义(P>0.05);C组在T3时MAP、HR明显下降;2组患者MAP、HR与T0比较差异无统计学意义(P>0.05);与T0时比较,两组患者各时点血浆NE浓度差异无统计学意义(P>0.05);C组在T1、T2、T3时血浆E浓度升高,差异有统计学意义(P<0.05);D组各时点血浆E浓度差异无统计学意义(P>0.05)。结论手术结束前30 min单次静脉泵注右美托咪啶0.5μg/kg可有效预防全麻拔管时的心血管反应,提高全麻苏醒期的质量。

作者邵娴刘静任静安丽吴军娜周文静岳婷

机构地区河北省石家庄市第四医院

出处《河北医药》 CAS 2016年第6期901-903,共3页 Hebei Medical Journal

关键词右美托咪啶妇科外科手术插管法气管内心血管反应腹腔内

分类号 R971.2 [医药卫生—药品]

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