摘要
目的探讨慢性阻塞性肺疾病患者血清淀粉样蛋白(SAA)、降钙素原(PCT)水平变化及其临床意义。方法选取COPD急性加重期、稳定期、健康对照者各30例,分别测定其血清SAA、PCT水平,并与COPD患者病情严重程度进行相关分析。结果 1 COPD急性加重组、稳定期组患者血清SAA、PCT水平均高于对照组水平(P<0.05);COPD急性加重组患者血清SAA、PCT水平高于稳定期组水平(P<0.05)。2 AECOPD病情程度与血清SAA、PCT水平的关系:AECOPD患者血清SAA、PCT水平与FEV1%预测值均呈负相关(r=-0.912、-0.772,P<0.01)。结论血清SAA、PCT测定值与COPD患者病情的严重程度具有相关性,检测血清SAA、PCT水平可以做为判断COPD病情严重程度的一项客观指标。
Objective To explore the changes and clinical implications of serum amyloid A protein and procalcitonin in patients with chronic obstructive pulmonary disease（COPD）. Methods Selected 30 cases patients with acute exacerbation of COPD（acute exacerbation group）, 30 cases patients with stable COPD（stable COPD group） and 30 cases healthy peoples（healthy control group）, measured serum SAA and PCT level and lung function of three groups, analyzed the result. Results 1The levels of SAA and PCT in serum of COPD were higher than that in control group, P〈0.05, the levels of SAA and PCT in AECOPD group was higher than that in stable COPD group, P〈0.05, the differences was statistically significant. 2The correlation analysis between serum concentration of SAA, PCT and FEV1% pred in patients with AECOPD： the levels of SAA and PCT was negatively correlated with FEV1% pred in patients with AECOPD, r=-0.912,-0.772, P〈0.01. Conclusion The serum levels of SAA and PCT in patients with COPD are correlated with disease severity of COPD. Detecting SAA and PCT in serum may be as one objective index and reflect the disease severity of COPD.
出处
《中国医药指南》
2016年第7期14-15,共2页
Guide of China Medicine
