基质金属蛋白酶降解胞外基质致未足月胎膜早破研究进展被引量：11

Research Progress of Matrix Metalloproteinases in Preterm Premature Rupture of Membranes through Degrading Extracellular Matrix

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摘要早产是威胁围生儿生命健康的首要病因。据统计,2012年中国早产发生率为8.1%。未足月胎膜早破（preterm premature rupture of membranes,PPROM）占早产的25%~30%,重要诱因为宫内感染。近年研究发现,PPROM的分子机制为胎膜组织中胞外基质过早降解,主要由基质金属蛋白酶（matrix metalloproteinases,MMPs）在胎膜组织中的激活引起。MMPs的激活原因有炎症因子的表达增高,如白细胞介素1（IL-1）,IL-6以及肿瘤坏死因子α（TNF-α）,但具体机制尚有待研究。MMPs在正常分娩与PPROM发生过程中的激活、分泌及其影响因素仍需探索,其可能作为预测妊娠结局的标记物,为PPROM的预防与治疗提供突破点。 Preterm birth is the first critical factor of life, threatening diseases for the perinatal. According to the statistics,the preterm birth rate in China reached 8.1% in 2012. And the frequency of preterm premature rupture of membranes（PPROM）is about 25%-30%, and intrauterine infection is the principal element. The recent research shows that a molecular mechanism of PPROM is advanced degradation of extracellular matrix, which due to the activation of matrix metalloproteinases（MMPs） in fetal membrane. The high expression of cytokines, such as IL-1, IL-6 and TNF-α, maybe the reason of MMPs′ activation. The process of activation and secretion of MMPs in term labor and preterm birth still need to be explored, which may be considered as a marker of pregnancy outcome. MMPs can provide a breakpoint of prevention and therapy for PPROM.

作者李雯常颖李星徐亚玲陈叙

机构地区天津市中心妇产科医院天津医科大学

出处《国际妇产科学杂志》 CAS 2016年第1期8-10,共3页 Journal of International Obstetrics and Gynecology

关键词基质金属蛋白酶类感染细胞因子类早产胎膜早破 Matrix metalloproteinases Infection Cytokines Premature birth Fetal membranes premature rupture

分类号 R714.433 [医药卫生—妇产科学]

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