摘要
β_1肾上腺素受体(β_1adrenergic receptor,β_1-AR)属于G蛋白偶联受体超家族,研究表明β_1-AR基因多态性与高血压发生、发展及临床药物疗效密切相关。β_1-AR基因多态性通过影响G蛋白-腺苷酸环化酶-环磷酸腺苷-蛋白激酶A(GsAC-c AMP-PKA)信号通路参与血压调控。同时,β_1-AR基因多态性是影响β-AR阻滞剂个体疗效差异的重要遗传因素。β_1-AR基因多态性的研究不仅揭示了调控高血压信号通路的新机制,而且为高血压临床个体化用药方案的制定提供理论依据和参考。
β_1 adrenergic receptor is one of G protein-coupled receptor superfamily. β_1-AR gene polymorphisms are closely related to the occurrence,development and treatment of hypertension. Numerous studies have shown that β_1-AR activates the GSAC-c AMP-PKA signal pathway to regulate the blood pressure. Furthermore,β_1-AR gene polymorphisms have been shown to cause differences in blood pressure response to β-AR blockers. Researches on β_1-AR gene polymorphisms not only reveal new insight into the hypertension regulation signals, but also provide the theoretical basis and guidance for individualized clinical treatment of hypertension.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2016年第2期225-230,共6页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
国家自然科学基金(81273594)
国家自然科学基金面上项目(81470535)
中南大学研究生自主探索创新项目(2015zzts320)
