摘要
目的研究慢性阻塞性肺疾病患者肺部感染对机体应激激素的表达情况,为该类患者机体不良应激的控制提供参考依据。方法选取2013年1月-2015年3月于医院进行诊治的45例慢性阻塞性肺疾病患者肺部感染为A组,选取同期45例慢性阻塞性肺疾病非肺部感染患者为B组,45例单纯肺部感染患者为C组,45名健康同龄人为D组,将4组研究对象的机体应激激素血清水平进行比较,并比较A组中不同肺部感染严重程度及肺部感染分期者的检测水平。结果 A组患者血清机体应激激素包括皮质醇(Cor)、醛固酮(ALD)、去甲肾上腺素(NE)及血管紧张素Ⅱ(Ang-Ⅱ)水平分别为(298.86±21.35)ng/ml、(28.76±3.24)ng/L、(284.98±17.37)ng/L及(68.54±7.28)ng/L,其均高于B、C组及D组,B组及C组则高于D组,且A组中轻度、中度及重度肺部感染者之间也有明显差异,急性期和恢复期患者的检测水平差异有统计学意义(P<0.05)。结论慢性阻塞性肺疾病患者肺部感染的机体应激激素呈现高表达状态,并且感染较重者表达水平相对更高。
OBJECTIVE To investigate the expression state of body stress hormones of the chronic obstructive pulmonary disease patients complicated with pulmonary infections so as to provide guidance for control of adverse body stress hormones.METHODS A total of 45 chronic obstructive pulmonary disease patients complicated with pulmonary infections who were treated in the hospital from Jan 2013 to Mar 2015 were assigned as the group A,meanwhile,45 patients with single chronic obstructive pulmonary diseases were chosen as the group B,45 patients with single pulmonary infections were set as the group C,and 45 healthy people were assigned as the group D.The levels of serum body stress hormones were compared among the four groups of study objects,and the levels of serum body stress hormones were compared among the patients with different severities of pulmonary infections and stages of pulmonary infections in the group A.RESULTS The levels of serum body stress hormones,including cortisol（Cor）,aldosterone（ALD）,norepinephrine（NE）,and angiotensinⅡ（Ang-Ⅱ）,were respectively（298.86±21.35）ng/ml,（28.76±3.24）ng/L,（284.98±17.37）ng/L,and（68.54±7.28）ng/L in the group A,higher than those in the group B,C,and D;the levels of the serum body stress hormones of the group B and C were higher than those of the group D.There was significant difference in the levels of the serum body stress hormones among the patients with mild,moderate,and severe pulmonary infections in the group A;there was significant difference in the levels of the serum body stress hormones between the patients with pulmonary infections in acute stage and the patients with pulmonary infections in recovery stage（P0.05）.CONCLUSIONThe body stress hormones of the chronic obstructive pulmonary disease patients complicated with pulmonary infections show high expression state,and the levels of the body stress hormones are even higher in the patients with severe infections.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2016年第6期1311-1313,共3页
Chinese Journal of Nosocomiology
基金
河南省科技厅基金资助项目(20001103)
关键词
慢性阻塞性肺疾病
肺部感染
机体应激激素
Chronic obstructive pulmonary disease
Pulmonary infection
Body stress hormone
