摘要
背景:目前已经发现许多细胞生长因子参与骨骼肌再生过程,并且需要多种细胞生长因子之间的协同配合,发挥再生修复的作用。目的:对多种细胞生长因子在促进损伤修复中可能的协同作用机制进行探讨和分析。方法:通过文献调查法,检索万方数据库和中国知网和Pub Med在运动性骨骼肌损伤及修复相关文献。中文检索词:"细胞生长因子;骨骼肌损伤;修复;成纤维细胞生长因子";英文检索词:"cell growth factor;skeletal muscle injury;repair;fibroblast growth factor"。分析国内外有关运动性骨骼肌损伤的研究成果,对细胞生长因子的分子生物学特性,及其与骨骼肌损伤修复的作用进行探讨。结果与结论:碱性成纤维细胞生长因子的基本生物学作用是促进细胞分裂增殖及促血管生成,是目前已知最强的促细胞生成因子,在骨骼肌损伤修复中体现出十分重要的作用。表皮生长因子由单核细胞及外胚层细胞合成,表皮生长因子最为突出的生物学特性是刺激体内多种类型组织细胞分裂和增殖、增强细胞移动、分裂生长及细胞间质蛋白的合成。胰岛素样生长因子由胰岛素样生长因子1和胰岛素样生长因子2两个密切相关的小多肽组成的家族,胰岛素样生长因子可以促进肌肉蛋白合成,促进成肌细胞的增殖、分化,参与骨骼肌损伤后的修复与再生,从而加速创伤肌肉的愈合。神经营养因子存在于感觉神经元周围的微量可溶性物质,由神经元的靶细胞产生,特异地促进神经元生长和维持,促进骨骼肌损伤修复。但多种生长因子协同修复运动性骨骼肌损伤的作用机制实验研究还只是初级阶段,仍然需要做进一步的研究。
BACKGROUND： A variety of cell growth factors are involved in skeletal muscle regeneration; moreover, these factors cooperate with each other to promote muscle repair and regeneration. OBJECTIVE： To explore the synergy mechanism of a variety of cell growth factors in promoting damage repair. METHODS： By using literature survey, Wanfang, CNKI and PubM ed databases were searched for articles related to exercise-induced muscle damage and repair using the keywords of ＂cell growth factor; skeletal muscle damage;repair; fibroblast growth factor＂ in Chinese and English, respectively. Research achievements related to exercise-induced muscle damage, molecular biological characteristics of cell growth factors and skeletal muscle injury repair are discussed. RESULTS AND CONCLUSION： Basic fibroblast growth factor plays a basic biological role to promote cell proliferation and angiogenesis, which is the strongest cytokine known to promote cell growth and reflects a very important role in skeletal muscle repair. Epidermal growth factor is synthesized by monocytes and ectodermal cells, which is prominent to stimulate the division and proliferation of a variety of tissues and cells, enhance cell movement, division and synthesis of interstitial protein. Insulin-like growth factors are a family of insulin-like growth factor 1-related and insulin-like growth factor 2-related peptides, which can promote muscle protein synthesis, promote muscle cell proliferation and differentiation, and participate in skeletal muscle regeneration and repair, thereby accelerating wound healing of the muscles. Neurotrophic factor is a kind of trace soluble substances around sensory neurons and produced by neuron-targeted cells, which can specifically promote neuronal growth and maintenance, and promote skeletal muscle repair. But studies on the synergy mechanism of a variety of cell growth factors in the repair of exercise-induced muscle damage are just at the initial stage, and further research is necessary.
出处
《中国组织工程研究》
CAS
北大核心
2016年第2期273-278,共6页
Chinese Journal of Tissue Engineering Research
基金
沈阳药科大学中青年教师事业发展支持计划资助课题
沈药大组人字【2014】9号文件~~
