摘要
恶性肿瘤侵袭、转移的发生不仅增加了患者的痛苦，还加大了临床治疗的难度，也是导致癌症患者死亡的主要原因。通过研究癌症的转移机制来寻找癌症复发转移的分子生物学标志物及抑制其复发转移的基因靶点，对临床治疗癌症有着重要的指导作用。恶性肿瘤的侵袭、转移是个复杂的过程，主要包括癌细胞本身的生物学特性、宿主细胞及细胞外基质与癌细胞的相互作用等。目前，研究上皮间质转化（EMT）在肿瘤发生及演进中的作用已成为肿瘤研究中的热点。而已知的上皮间质化的标志物包括上皮标志蛋白和间质标志蛋白，上皮标志蛋白最主要的是E-钙黏蛋白（E-cadherin），而间质标志蛋白主要有N-钙黏蛋白（N-cadherin）和波形蛋白（vimentin），因此现将这三者近十年的相关研究作一综述。
The invasion and metastasis of tumor as the primary cause of death in cancer increases not only the patient＇s suffering, but also the difficulty of clinical treatment. It is an important guiding to find the molecular biological tumor markers and gene targets of antirecurrence and antimetastasis for clinical treatment. The invasion and metastasis of tumor is a complex process including the biological characteristics of the cancer, interaction among host cells, extracellular matrix and cancer cells, etc. Recently, epithelial mesenchymal transition （EMT） is becoming a hot spot in oncology research by virtue of its effect on genesis and development of tumor. Currently, the known markers of EMT include epithelial marker proteins mainly containing E-cadherin and interstitial marker proteins mainly containing N-cadherin and vimentin. It is necessary to make a summary among the studies on three proteins.
出处
《肿瘤研究与临床》
CAS
2016年第2期132-136,共5页
Cancer Research and Clinic
