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卵巢癌组织中ABCF2、ABCG2阳性表达及意义 被引量:3

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摘要 目的探讨ABCF2、ABCG2在卵巢癌组织中的阳性表达及其与化疗耐药的关系。方法选择卵巢癌患者94例,均行肿瘤细胞灭活术配合紫杉醇类与铂类联合化疗,并对化疗耐药情况进行随访。采用免疫组化SP法观察卵巢癌组织中ABCF2和ABCG2表达,观察其阳性表达与卵巢癌患者临床病理特征的关系。采用Logistic回归分析对化疗耐药的相关因素进行分析。结果卵巢癌组织中ABCF2阳性表达与肿瘤病理类型和肿瘤分级无关(P均>0.05),与肿瘤分期、化疗耐药情况有关(P均<0.05)。卵巢癌组织中ABCG2阳性表达与肿瘤病理类型、肿瘤分期、肿瘤分级无关(P均>0.05),与化疗耐药情况有关(P<0.05)。Logistic回归分析显示,ABCF2和ABCG2阳性表达是卵巢癌患者发生化疗耐药的独立危险因素(OR分别为1.067和1.132,P均<0.05)。结论肿瘤组织ABCF2和ABCG2阳性表达可能是卵巢癌患者发生化疗耐药重要原因。
出处 《山东医药》 CAS 北大核心 2016年第8期65-67,共3页 Shandong Medical Journal
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